龙鳖胶囊治疗膝骨关节炎临床疗效及其对生活质量的影响

Clinical Efficacy and Quality of Life of Knee Osteoarthritis Patients Treated with Longbie Capsule

目的:观察龙鳖胶囊治疗膝骨关节炎的临床疗效及其对膝骨关节炎患者生活质量的影响。方法:将符合纳入标准的88例患者,随机分为龙鳖胶囊组44例和塞来昔布组44例,分别给予口服龙鳖胶囊和塞来昔布,两组均以4周为观察期,对两组患者治疗后的临床疗效、VAS评分、Lequesne指数、胃肠道不良反应、关节炎影响测定量表评分进行评价。结果:龙鳖胶囊组总有效率92.25%,塞来昔布组总有效率90.00%,两组总有效率无显著性差异(P>0.05)。与治疗前比较,龙鳖胶囊组和塞来昔布组的VAS评分、Lequesne指数、关节炎影响测定量表评分均较前明显改善,具有显著性差异(P<0.01)。治疗期间,龙鳖胶囊组出现胃肠道反应4例,塞来昔布组出现胃肠道反应3例,两组不良反应发生率比较,无显著性差异(P>0.05)。治疗后组间比较,龙鳖胶囊组和塞来昔布组在VAS评分、Lequesne指数方面无显著性差异(P>0.05);龙鳖胶囊组的关节炎影响测定量表评分低于塞来昔布组,具有显著性差异(P<0.01)。结论:采用龙鳖胶囊和塞来昔布治疗膝骨关节炎,均可有效缓解症状、改善膝关节功能,具有良好的有效性和安全性;但龙鳖胶囊在改善生活质量方面优于塞来昔布。

Objective ： To evaluate the clinical efficacy and and quality of life of knee osteoarthritis patients when treating with Longbie Capsule. Methods： Eighty - eight patients who met the inclusion criteria were randomly divided into Longbie Capsule group and Celecoxib group. The Longbie Capsule group was treated with Longbie Capsule and the Celecoxib group was with Celebrex. The observation period for the two groups was 4 weeks. The clinical efficacy, VAS Scale, Lequesne index, gastrointestinal adverse reaction and the arthritis impact measurement scale of two group were compared before and after treatment. Results： The total effective rate of Longbie Capsule group was 92.25% and of the Celecoxib group was 90.00%. There was no significant difference between the two groups（P 〉 0.05 ）. The VAS Scale, Lequesne index and the arthritis impact measurement scale of two groups after treatment were better than those before treatment（P 〈 0. 01 ）. During treatment, there were four cases which had gastrointestinal adverse reaction in Longbie Capsule group and three cases in Celecoxib group, but there was no significant difference between the two groups （P 〉 0. 05 ）. There was no significant difference of the VAS Scale and Lequesne between two groups after treatment（ P 〉 0. 05 ）. After treatment, the arthritis impact measurement scale of Longbie Capsule group was lower than that of the Celecoxib group（ P 〈 0. 01 ）. Conclusions： Both Longbie Capsule and Celecoxib could effectively relieve symptoms and improve the function of knee joint of knee osteoarthritis patients, with good clinical efficacy and safety. Longbie Capsule was better in improving the quality of life than celecoxib.