盆宁颗粒干预亚临床子宫内膜炎性临床观察

Intervention of Penning Granules on Subclinical Endometritis

目的:从宫腔镜观察、病理分析、内膜局部分子水平、疗效评判等多个角度分析盆宁颗粒治疗亚临床子宫内膜炎导致的不孕不育患者的作用机制。方法:应用宫腔镜技术观察不明原因不孕、复发性流产、反复胚胎移植失败患者的内膜形态,并定点活检,分析MUC-1、HIF-1α的表达情况。符合诊断标准的58例随机分为盆宁颗粒组(n=33)和对照组(n=25),经治疗后再次行宫腔镜下活检,根据宫腔镜表现、病理分析、分子水平对比盆宁颗粒组和对照组治疗效果。最后疗程结束半年后随访观察患者妊娠情况。结果:从宫腔镜表现、病理分析、分子水平、妊娠情况4个方面分析盆宁颗粒组和对照组的治疗效果,盆宁颗粒组疗效明显优于对照组。结论:盆宁颗粒治疗亚临床子宫内膜炎效果显著,优于现代医学的抗生素治疗。亚临床性子宫内膜炎是导致部分患者不孕、复发性流产的重要因素,盆宁颗粒可促进子宫内膜容受性,提高临床妊娠率。

Objective ： To analyze the functional mechanism of Penning Granules treating patients with infertility led by subclinical endometritis from hysteroscopy observation, pathological analysis, molecular level of local endometrium and treatment assessment. To discuss the correlation between Penning Granules and endometrial receptivity. Methods： With the application of hysteroscopy, different morphologies of endometrium in patients with sterility of unknown origin, recurrent miscarriage and repeated implantation failure were observed and biopsied at fixed points to analyze the expression of MUC -1 and HIF- 1α. A total of 58 cases according to those diagnostic criteria above were randomly divided into Penning Granules group （n = 33 ） and control group （n = 25 ）. The second biopsy under the hysteroscopy was can＇ied out after the treatment and then the curative efficacy of both the Penning Granules group and control group were compared according to the result of hysteroscopy observation, pathological analysis and molecular level of endometrium. Follow - up visits were arranged lastly to observe patients＇ pregnancy rate half a year after the treatment. Results ： By comparing the curative efficacy of Penning Granules group and control group from hysteroscopy observation, pathological analysis, molecular level and pregnancy rate, Penning Granules group was significantly effective than the control group. Conclusion： Penning Granules have a significant effect on treating the subclinical endometritis, which is superior to the antibiotic therapy of conventional medicine. Subclinical endometritis is a vital factor for some patients who suffer from infertility and recurrent miscarriage. And Penning Granules can increase the endometrial receptivity and enhance the clinical pregnancy rate.