热淋清颗粒对肾结石术后尿路感染的预防及促排石、止痛效果观察

Observation on Effects of Relinqing Granule in Prevention of Urinary Tract Infection after Kidney Calculi Operation,Promotion of Removing Calculi and Relief of Pain

目的:探讨热淋清颗粒对肾结石术后尿路感染的预防作用及对术后排石、疼痛的影响。方法:选择2012年5月—2015年4月接受手术治疗的72例肾结石患者,按照随机数字表法分为对照组与观察组各36例,对照组术后静滴盐酸左氧氟沙星氯化钠注射液干预,观察组在此基础上加用热淋清颗粒治疗,两组均治疗1周,观察两组治疗效果,统计结石排出率及排净时间,观察患者尿痛、尿频、血尿、肾区疼痛、叩击痛等症状及体征评分改善情况,监测治疗期间不良反应发生情况,记录两组术后1个月内尿路感染发生率。结果:1观察组总有效率略高于对照组,但对比差异无统计学意义(P>0.05);2观察组治疗1周血尿、尿频、尿痛、尿急、肾区疼痛、叩击痛等症状积分均低于对照组,对比差异有统计学意义(P<0.05);3观察组结石排出率高于对照组(P<0.05),结石排净时间短于对照组,对比差异有统计学意义(P<0.05);4两组治疗期间不良反应发生率相近(P>0.05),均未见严重不良反应;5观察组尿路感染发生率低于对照组,对比差异有统计学意义(P<0.05)。结论:热淋清颗粒用于防治PCNL术后尿路感染整体效果好,可促进结石排出,减轻尿痛、肾区疼痛等症状,且安全性高,不良反应少。

Objective：To investigate the preventive effect of Relinqing Granule on urinary tract infection after kidney calculi operation and the effects on removing calculi and pain after operation. Methods ： Seventy - two cases of patients with kidney calculi who were treated by operation in our hospital between May 2012 and April 2015 were selected. According to the random number table method, the patients were divided into control group and observation group with 36 cases in each. The control group was treated with intravenous infusion of Levofloxacin Hydrochloride and Sodium Chloride Injection after operation. On the basis, the observation group was additionally treated with Relinqing Granule. Both of the two groups were treated for 1 week. The treatment effects of the two groups were observed. The rate of stone being removed and time of removing clearly were statistically analyzed. The relief of dysuria, frequent micturition, hematuria, renal pain, percussion pain and other symptoms and signs scores were observed. The incidence of adverse reactions during treatment was monitored and the incidence rates of urinary tract infection in the two groups in postoperative 1 month were recorded. Results ：（1）Total effective rate of observation group was slightly higher than that of the control group（ P 〉 0. 05 ）. （2）After 1 week of treatment, the scores of hematuria, frequent micturition, dysuria, urgent urination, renal pain, percussion pain and other symptoms in the observation group were lower than those in the control group （P 〈 0.05）. （3）The rate of stone being removed in the observation group was higher than that in the control group （P 〈 0. 05 ） and the time of removing clearly was shorter than that in the control group （P 〈 0. 05）. （4）The incidence rates of adverse reactions in the two groups were similar （ P 〉 0.05）. There were no severe adverse reactions in the two groups. （5）The incidence of urinary tract infection in observation group was lower than that in the control group （ P 〈 0. 05 ）. Conclusion ： The overall effect of Relinqing Granules applied in prevention of urinary tract infection after PCNL is good. It can promote stone expulsion and reduce the symptoms such as dysuria and renal pain, with high safety and fewer adverse reactions.