早期应用益生菌对新生儿胆红素的影响

The Influence of Early Application of Probiotics in Neonatal Bilirubin

目的:探讨生后5 h开始应用益生菌对新生儿胆红素和新生儿高胆红素血症发生率的影响。方法:选择2014年11月至2015年11月在我院出生的新生儿202例,采用随机数字表法分为观察组与对照组各101例。观察组于出生5 h内即用奶瓶或鼻饲(口饲)喂服布拉氏酵母菌0.25 g,每天1次,连用5 d。每天监测两组新生儿胆红素动态变化情况。统计日龄1 d、2 d、3 d、4 d胆红素平均值。结果:两组新生儿经皮胆红素测定日龄1 d时比较差异无统计学意义(P>0.05);对照组日龄2 d时的胆红素均值为(11.28±2.88)mg/d L、日龄3 d时为(13.71±3.35)mg/d L、日龄4 d时为(14.68±3.41)mg/d L,观察组日龄2 d时的胆红素值为(10.07±2.22)mg/d L、日龄3 d时为(12.58±0.38)mg/d L、日龄4 d时为(13.52±2.23)mg/d L,对照组明显高于观察组,差异有统计学意义(P<0.05)。观察组高胆红素血症发生率为8.91%,明显低于对照组的21.78%,差异有统计学意义(P<0.05)。益生菌对新生儿咽下综合征、新生儿湿肺、新生儿肺炎发病率无影响(P>0.05)。结论:早期应用布拉氏酵母菌可以降低新生儿血清胆红素水平和高胆红素血症发生率。

Objective： To investigate the effect of probiotics application 5 hours after birth in neonatal bilirubin and the incidence of hyperbilirubinemia. Methods： Two hundreds and two neonates in our hospital were divided into observation group and control group from November 2014 to November 2015. One hundred and one neonates of the observation group were given Saccharomyces boulardii 0.25 g,once a day,the treatment lasted for 5 days. The levels of bilirubin were monitored everyday in two groups and the mean of bilirubin in 1,2,3,4 days old were monitored. Results： In the observation group,the serum bilirubin levels were not statistically different compared to the control group at the first day after birth. The serum bilirubin levels in the observation group at the second,the third and the fourth day after birth were（ 10.07±2.22） mg / d L,（ 12.58±0.38） mg / d L,（ 13.52±2.23） mg / d L,in the control were（ 11.28±2. 88） mg / d L,（ 13.71±3.35） mg/d L,（ 14.68±3.41） mg/d L,there were significantly differences two groups（ P〈0.05）. The incidence of neonatal hyperbilirubinemia was 8. 91% in observation group,it was obviously lower than the control group（ 21. 78%）,the difference was statistically significant（ P 〈0. 05）. There were no significantly differences in neonate swallowing syndrome,wet lung of the newborn,neonatal pneumonia between two groups（ P〈0.05）. Conclusion： Early application of Saccharomyces boulardii can reduce the level of bilirubin and the incidence of neonatal hyperbilirubinemia,and has no effect on the incidence of other diseases.