血清ACA、sHLA-G等在预测习惯性流产中的应用价值

The predictive value of serum ACA combined with IL-10 and s HLA-G for habitual abortion prediction

目的探讨血清抗心磷脂抗体(ACA)联合白细胞介素-10(IL-10)及可溶性人白细胞抗原(s HLA-G)水平在预测习惯性流产中的应用价值。方法选取2014年4月~2015年2月在山西省运城市中心医院产检的有习惯性流产史的早期妊娠孕妇42例为试验组,另选取同期本院无自然流产史早期妊娠孕妇42例作为对照组。分别抽取两组患者静脉血,采用酶联免疫(ELISA)法定量检测两组样本血清中的ACA、IL-10及s HLA-G水平,并采用ROC曲线分析血清中的ACA、IL-10及s HLA-G水平用于预测习惯性流产的价值。结果试验组的血清ACA水平明显高于对照组,而IL-10及s HLA-G水平则明显低于对照组,差异有统计学意义(P<0.05)。ROC曲线分析结果显示,习惯性流产患者血清ACA联合IL-10及s HLA-G水平预测习惯性流产的ROC曲线下面积、灵敏度、特异度均较高,血清ACA、IL-10及s HLA-G水平单独预测习惯性流产的ROC曲线下面积、灵敏度、特异度均较高。结论检测早期妊娠患者血清中的ACA、IL-10及s HLA-G水平对习惯性流产的预测有一定价值,密切留意有流产史孕产妇的血清ACA、IL-10及s HLA-G水平,并及时对存在习惯性流产风险的孕产妇进行干预,有助于预防习惯性流产的发生。

Objective To analysis the predictive value of serum anticardiolipin antibody（ACA）,Interleukin-10（IL-10）and soluble human leucocyte antigen（s HLA-G）for habitual abortion prediction. Methods 42 early pregnancy patients that with recurrent abortion history in our hospital from April,2014 to February,2015 were enrolled in the research group,the other 42 cases early pregnancy women without recurrent abortion as were in the control group. The levels of serum ACA,IL-10 and s HLA-G was were measured by the enzyme-linked immunoabsorbent assay（ELISA） methods. the predictive value of serum ACA,IL-10 and s HLA-G was analysis by ROC curve. Results The serum ACA level for the patents in research group was higher than that in control group obviously,however the IL-10 and s HLA-G levels were lower than those in control group obviously,all the difference was statistically significant（P〈0.05）. ROC curve analysis results showed that area under the ROC curve was bigger,sensitivity and specificity were better when predict the recurrent abortion by combine the serum ACA,IL-10 and s HLA G level rather than by single of them（P〈0.05）. Conclusion It is valuable to predict and diagnosis recurrent abortion in the beginning of pregnancy by measure the serum ACA,IL-10 and s HLA G level,close monitoring to the level of serum ACA,IL-10 and s HLA G helps to reduce the risk of recurrent miscarriage.