种植窗期子宫内膜微血管密度与胚胎种植结局的相关性探讨

Relationship between microvessl density and vitro fertilization treatment outcome in the window endometrium of implantation

目的:探讨种植窗期子宫内膜微血管密度(MVD)对评价胚胎种植结局的价值。方法:选择行体外受精-胚胎移植(IVF-ET)治疗的患者60例,根据新鲜周期是否妊娠分为临床妊娠组(30例)及未妊娠组(30例)。全部患者均于行IVF-ET前一个月经周期排卵后的第7天用一次性宫腔组织吸引管获取子宫内膜组织,采用免疫组化的方法进行MVD测定。结果:临床妊娠组MVD高于未妊娠组,差异有统计学意义。未妊娠组HCG日孕酮高于临床妊娠组,临床妊娠组三线型子宫内膜比例高于未妊娠组,差异均有统计学意义。结论:HCG日孕酮提前升高,导致妊娠率下降。种植窗期子宫内膜微血管密度对预测妊娠结局有一定的临床意义。

Objective：To evaluate the value of endometrial microvessel density（ MVD） in assessing in vitro fertilization（IVF） treatment outcome during the window endometrium of implantation. Methods：A total of 60 patients undergoing in vitro fertilization and embryo transfer（ IVF- ET） treatment were analyzed retrospectively. The subjects were divided into clinical pregnancy group（30 cases） and nonpregnant group（30 cases） according to the IVF- ET outcome. Endometrial tissues were collected 7 ~ 9 days after the natural ovulation prior to IVF- ET for measurement of the endometrial MVD. Results：The endometrial MVD was significantly higher in the clinical pregnancy group than in the nonpregnant group. The progesterone was significantly higher in the nonpregnant group than in the clinical pregnancy group while the proportion of triple- line pattern endometrial was significantly higher in the clinical pregnancy group than in the nonpregnant group. Conclusion：The progesterone elevation on the day of HCG is negatively related to the pregnancy rate. The endometrial MVD in the window endometrium of implantation has clinical significance in forecast the IVF treatment outcome.