七氟醚丙泊酚复合麻醉对老年骨科术后认知功能的影响

Effects of Sevoflurane and Propofol Combined Anesthesia on Postoperative Cognitive Function in Elderly Orthopedic Patients

目的:探讨七氟醚与丙泊酚复合麻醉对老年骨科患者术后认知功能的影响。方法:选择在某院接受骨科手术治疗的老年患者90例,按麻醉给药方式不同分为P组(丙泊酚复合麻醉组)和S组(七氟醚复合麻醉组),每组各45例,手术过程中记录患者手术时间、麻醉时间、出血量、术后睁眼时间、拔管时间等一般手术情况,并采用简易精神状态量表(MMSE)对两组患者术前1d、术后1d,2d,3d的认知功能进行比较。结果:两组患者一般手术情况(手术时间、麻醉时间、出血量、睁眼时间、拔管时间)比较差异不显著(P>0.05),术后两组患者MMSE评分均出现先下降后上升的趋势,术后第2dS组患者MMSE评分显著高于P组,组间比较差异显著(P<0.05)。结论:七氟醚与丙泊酚复合麻醉可降低患者的认知功能,但术后均可逐步恢复,其中七氟醚复合麻醉恢复患者认知功能的时间短于丙泊酚复合麻醉,效果明显,值得临床推广使用。

Objective：To investigate the effects of sevoflurane and propofol combined anesthesia on cognitive function in elderly orthopedic patients.Methods：90elderly orthopedic patients treated in a hospital were selected and divided into group P（propofol conbined anesthesia group）and S group（sevoflurane conbined anesthesia group）according to the anesthesia administration methods,with 45 cases in each group.The general surgical conditions（operation time,anesthesia time,amount of bleeding,eye opening time,and extubation time）were recorded during the operation,and the patients＇ cognitive function before anesthesia and postoperative 1d,2dand 3dwere compared by using min-mental state examination（MMSE）.Results：There was no significant difference in general surgical conditions between the two groups（P 〉0.05）,the postoperative MMSE scores of two groups were firstly decreased and then increased,the MMSE score at 2days after surgery in the group S was significantly higher than that of group P（P〈0.05）.Conclusion：Sevoflurane and propofol combined anesthesia can reduce cognitive function in elderly orthopedic patients,but it were able to recover in a few days,and the recovery time of cognitive function of patients treated with sevoflurane combined anesthesia were shorter than that of propofol combined anesthesia,with obvious effect,which is worthy of clinical application and promotion.