新生儿败血症80例临床资料报道分析

Analysis of Clinical Data of 80 Cases of Neonatal Septicemia

目的:对新生儿败血症患儿的临床特点、病原菌等情况进行分析,为新生儿败血症患儿的诊断以及治疗提供依据。方法:选取新生儿败血症患儿100例,时间为2012年1月~2015年12月,对这100例新生儿败血症患儿的临床资料、病原菌检验结果等情况进行分析。结果:新生儿败血症患儿的主要临床症状包括:黄疸、呼吸困难、呼吸急促/吐沫、咳嗽、拒乳/吮乳差、体温异常、反应差、呕吐、腹泻以及皮肤脓疱等,与其他症状相比,黄疸症状患儿较多(P<0.05);患儿的合并症主要为呼吸窘迫综合征、脐炎、肺炎、脓疱疮、脑膜炎(化脓性)、脑病(缺氧缺血性)、小肠结肠炎(坏死性)、颅内出血;药敏结果为:致病菌主要为革兰氏阳性菌以及革兰氏阴性菌;多数病原菌对万古霉素、舒巴坦、头孢菌类(第三代)、喹诺酮类以及氨基糖甙类抗生素较为敏感,对碳青霉烯类以及头孢吡肟类抗生素有着高度的敏感性;经综合治疗后,97例治愈,3例自行出院(失访)。结论:新生儿败血症患儿的临床表现并不具有特异性,导致患儿出现败血症的主要致病菌为葡萄球菌,为新生儿败血症患儿实施治疗的主要方法为综合治疗(抗生素为主)。

Objective：To analyze the clinical characteristics and pathogenic bacteria of neonatal neonatal septicemia,and to provide evidence for the diagnosis and treatment of neonatal septicemia.Methods：100cases of children with neonatal septicemia from December 2015 to January 2012 were selected,and the clinical data and the inspection results of pathogenic bacteria of 100 cases of neonatal septicemia were analyzed.Results：The main clinical symptoms of neonatal septicemia included jaundice,dyspnea,polypnea/spit,cough,milk refusal/poor sucking,abnormal body temperature,poor response,vomiting,diarrhea and skin pustules,compared with other symptoms,the number of children with jaundice symptoms were more（P〈0.05）;The main complications of children were respiratory distress syndrome,omphalitis,pneumonia,impetigo,meningitis（suppurative）,encephalopathy（hypoxic ischemic）,enterocolitis（necrotic）,intracranial hemorrhage;The drug sensitivity results were that the main pathogenic bacteria was gram positive bacteria and gram negative bacteria;Most of pathogenic bacteria was sensitive to vancomycin,sulbactam,cephalosporin fungi（third generation）quinolone and aminoglycoside antibiotics,and most of pathogenic bacteria was highly sensitive to carbapenems and cefepime;After the comprehensive treatment,97 cases were cured,and 3patients were discharged from hospital.Conclusion：The clinical manifestations of children with neonatal septicemia has no specificity.The main pathogenic bacteria resulting in children with septicemia is staphylococcus aureus,and the main treatment for neonatal septicemia is comprehensive treatment（antibiotics based）.