咖啡酸片预防GP方案治疗晚期非小细胞肺癌所致白细胞减少的临床观察

Clinical Observation of Caffeic Acid Prevention GP Regimen in the Treatment of Leukopenia Caused by Advanced Non-small Cell Lung Cancer

目的:观察咖啡酸片预防GP方案治疗晚期非小细胞肺癌所致白细胞减少的临床观察。方法:将60例晚期非小细胞肺癌随机分为观察组与对照组,两组同时给予吉西他滨针1000mg/m2,d1,8,顺铂针75mg/m2,d1-3。观察组予开始化疗第1d给予咖啡酸片0.3g,口服,3次/d。2个周期后根据患者白细胞减少情况予以重组人粒细胞集落刺激因子皮下肌注升白细胞治疗,观察白细胞的下降程度,重组人粒细胞集落刺激因子使用使白细胞恢复至正常所用的时间。结果:观察组无明显白细胞下降2例,Ⅰ度骨髓抑制(白细胞计数3.0~4.0×109/L)13例,Ⅱ度骨髓抑制(白细胞计数2.0~3.0×109/L)8例,Ⅲ度骨髓抑制(白细胞计数1.0~2.0×109/L)5例,Ⅳ度骨髓抑制(白细胞计数0~1.0×109/L)2例,与对照组相比P<0.05,有统计学意义。结论:咖啡酸片对预防GP方案治疗晚期非小细胞肺癌所致白细胞减少有一定的临床疗效,值得进一步研究。

Objective：To observe the clinical effect of caffeic acid prevention GP regimen in the treatment of leukopenia caused by advanced non-small cell lung cancer.Methods：60cases of patients with advanced nonsmall cell lung cancer were randomly divided into observation group and control group.Both of two groups were given gemcitabine injection（1000mg/m2,d1,8）and cis-platinum injection（75mg/m2,d1,3）.Then the observation group was given caffeic acid（oral,three times a day）from the first day of chemotherapy.After two cycles,patients received according to the patients with leucopenia cases received treatment of raising the white blood cells by subcutaneous injection of recombinant granulocyte colony stimulating factor.At last,the decrease of white blood cells and the time of white blood cells recovering to the normal were observed after the use of recombinant granulocyte colony stimulating factor.Results：In the observation group,2cases had no obvious decrease of white blood cells,13 cases had I bone marrow suppression（white blood cell count 3.0-4.0×109/L）,8cases had II degree of bone marrow suppression（white blood cell count,2.0-3.0×109/L）,5cases had III degree of bone marrow suppression（white blood cell count 1.0-2.0×109/L）,and 2cases had IV degree of bone marrow suppression（white blood cell count 0-1.0×109/L）.Compared with the control group,the differences were statistically significant（P〈0.05）.Conclusion：Caffeic acid prevention GP regimen in the treatment of leukopenia caused by advanced non-small cell lung cancer has a certain clinical curative effect,which is worthy of further study.