调脂和降糖方案在代谢综合征治疗中的应用与对比

Application and Contrast of Lipid Regulation and Reducing Blood Glucose Schemes in the Treatment of Metabolic Syndrome

目的:研究和比较调脂和降糖方案治疗代谢综合征的临床疗效。方法:选择年龄在65周岁及以上的代谢综合征患者100例,采用随机平行对照方法分为调脂组和降糖组。调脂组给予他汀类代表药物洛伐他汀口服治疗,降糖组给予降糖治疗推荐首选药物二甲双胍口服治疗,观察给药治疗前后受试者TG(甘油三酯)、HDL-c(高密度脂蛋白)、FPG(空腹血糖)3个指标的变化情况。结果:两组药物治疗前后对TG、HDL-c、FPG3个指标的影响均有显著性差异。对HDL-c、TG的影响,降糖组与调脂组差异没有统计学意义(P>0.05)。但是对FPG的影响,两组治疗效果有统计学意义(P<0.05)。结论:调脂和降糖方案对代谢综合征患者的治疗均有较好疗效,但降糖方案在改善胰岛素抵抗,降低血糖方面疗效相对更具有优势。

Objective：To study and compare the clinical effect of lipid regulation and reducing blood glucose schemes in the treatment of metabolic syndrome.Methods：100cases of patients aged 65 and over with metabolic syndrome were selected and divided into lipid regulation group and reducing blood glucose group using random parallel control method.The lipid regulation group was given lovastatin oral treatment,and the reducing blood glucose group was given melbine oral treatment.The changes of three indexes of TG,HDL-c and FPG before and after treatment were observed.Results：The treatment impact on TG,HDL-c,and FPG of two groups drugs were significantly different.There was no significant difference in HDL-c and TG between the two groups（P〉0.05）.However,the difference of effect on FPG of two groups was statistically significant（P〈 0.05）.Conclusion：Both of two lipid regulation and reducing blood glucose programs have good effect in the treatment of patients with metabolic syndrome,but the reducing blood glucose scheme is more advantageous in improving insulin resistance and reducing blood glucose.