基于专利分析的细胞治疗技术在抗癌领域的发展态势

Development Trend of Cell Therapy in Anti-cancer Based on Patent Analysis

以德温特创新索引专利数据库为依托,对2006~2016年间相关专利进行检索,综合运用统计分析和可视化分析,进行细胞治疗技术专利申请趋势分析、学科类别分析、专利权人构成分析、发明人合作网络分析、专利热点领域分析、德温特手工代码技术演进分析、高被引用专利分析,研究结果显示:1)该领域细胞治疗技术专利申请呈现波浪式上升状态,技术涉及学科高度集中;2)欧美等发达国家引领技术发展方向,但整个领域技术合作范围相对有限,合作程度比较低;3)该领域热点主要集中在细胞来源、细胞培养、抗原抗体制备、细胞体外诱导材料、工艺、体外抗炎抗感染及药物组合治疗等方面;4)从时间演进变化看,细胞来源与细胞培养是恒定主题,随着技术的发展,工艺的优化、治疗方案的多样化方面的专利正逐步涌现,成为新的焦点。立足我国产业发展实际,本文进一步提出了细胞治疗技术在抗癌领域的发展建议。

Based on statistical analysis and visualization method ,the cell therapy patents from 2006 to 2016 collected by the Derwent Innovation Index databases are analyzed, analyzing such as patent trend, category, proprietor, inventor network, hot sports, Derwent Manual Code and high cited patents. The results show： 1 ） Cell therapy technology presents a wave like rise and the technology involves highly concentrated category; 2 ） Developed countries lead the technical development direction, but the technical cooperation between inventor is low; 3） Hot spots mainly concentrate on the source of cell, cell culture, antigen antibody preparation,induction materials, process, anti-inflammatory and anti infection and so on. 4） From the time evolution, the cell source and cell culture is a constant theme. With the development of technology, process optimization,the diversification of treatment programs are gradually emerging as a new focus. Based on the practical situation of the develop- ment of cell therapy technology in China, the suggestion is proposed.