前臂皮瓣、股前外侧穿支皮瓣及颏下岛状皮瓣修复舌癌患者术后生活质量评估

Assessment of life quality of for patients after tongue reconstruction with radial forearm free flap,anterolateral thigh perforator flap or submental island flap

目的 :评估应用前臂皮瓣(radial forearm free flap,RFFF)、股前外侧穿支皮瓣(anterolateral thigh perforator flap,ALT)、颏下岛状皮瓣(submental island flap,SIF)修复舌癌患者手术相关因素及术后生活质量,明确舌癌切除的最佳修复方法。方法:2004年10月—2014年10月期间,应用RFFF、ALT、SIF修复90例舌癌患者术后缺损,随访观察半年,分析患者手术时间、住院天数、皮瓣面积及3种皮瓣修复对患者术后生存质量的影响。患者在手术后复诊时自行完成华盛顿大学生存质量问卷量表第4版(University of Washington Quality of Life Questionnaire version 4,UW-QOL v4)填写。采用SPSS17.0软件包对数据进行统计学处理。结果 :3组手术时间差异显著(P<0.05)。ALT组与SIF组住院天数差异显著(P<0.05),其余2组无显著差异。3组皮瓣面积差异显著(P<0.05)。外貌方面,ALT组与RFFF组有显著差异(P<0.05),其余2组无显著差异。行动方面,ALT组与SIF组、ALT组与RFFF组有显著差异(P<0.05),SIF组与RFFF组无显著差异。3组在咀嚼、吞咽、语言、疼痛等10方面及总QOL得分无显著差异。结论:3种皮瓣修复舌癌术后缺损总生存质量无显著差异,均为舌癌术后缺损修复的理想皮瓣。皮瓣选择需根据组织缺损的类型及大小、手术条件与患者的自身情况等综合考虑。

PURPOSE： The aim of this study was to evaluate operation-related factors and quality of life （QOL） for patients after tongue reconstruction with radial forearm free flap （RFFF）, anterolateral thigh perforator flap （ALT） or submental island flap （SIF）. METHODS： Totally 59 patients, diagnosed as tongue carcinoma, received glossectomy and simultaneous reconstruction with free flaps including RFFF, ALT or SIF in the Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, China Medical University from October 2004 to October 2014. All patients were followed up for 6 months and completed the University of Washington Quality of Life scale Version 4 questionnaires. The postoperative QOL was compared among the three groups. The data were analyzed using SPSS 21.0 software package. RESULTS： The operation duration of SIF group was significantly shorter than those of RFFF group or ALT group （P〈0.05）. The ALT group had a longer hospitalization time. There were statistically differences among the 3 groups regarding to the size of reconstructed defects. Action QOL score of the ALT group was significantly lower than those of RFFF group and SIF group. There was no significant difference in the total QOL score including chewing, swallowing, speech and postoperative pain among the 3 groups. CONCLUSION： In summary, there may be functional disability for patients after glossectomy and simultaneous reconstruction. The quality of life would be acceptable after tongue reconstruction with RFFF, ALT and SIF.