瓦楞子炮制历史沿革及现代研究进展

Historical Evolution and Modern Research Progress of Arcae Concha

通过对古代及现代医药文献进行查阅、整理、分析,总结了瓦楞子的炮制历史沿革及现代研究概况。以《历代中药炮制资料辑要》一书为线索,查阅三国至清朝时期本草原著30部,并查阅《中国药典》9部,《全国中药炮制规范》1988年版和地方中药饮片炮制规范22部,对古今文献中所收载的瓦楞子炮制方法加以归纳、总结。瓦楞子炮制历史悠久,历代的炮制方法有生品研碎、火煅、煅醋淬、煅醋煮、煅盐水煮等,目前全国各地主要沿用了煅法。现行的炮制规范中对煅制工艺和火候的表述过于广泛,缺乏定性定量指标和统一的炮制质量标准,而且现行的质控标准主要以碳酸钙的含量作为评价指标,需进一步对炮制工艺进行研究,包括煅制火候、温度、时间、煅淬次数、粉碎粒度等具体工艺参数,并比较不同炮制工艺和炮制方法对其化学成分含量的影响,以发挥瓦楞子的最佳药物疗效。另外应进一步对瓦楞子中有机质类成分及某些微量元素进行研究,以增加其质控指标或方法,从根本上全面控制瓦楞子的内在质量。

On the basis of a comprehensive consulting, sorting and analyzing of the ancient and modern medical literature, this paper summarizes the general situation of the historical development and modern research of Arcae Concha. Taking the book A Summary of Chinese Medicine Processing Data Through History as clue, the author refers to 30 classical medical works written from the Three Kingdoms period to the Qing dynasty, 9 versions of Chinese Pharmacopoeia, the 1988 edition of The National Chinese Medicine Processing Criterion, and 22 books of local Chinese medicine processing criterion. After that, the author summerizes all the processing methods of Arcae Concha in ancient and modern literature. Arcae Concha processing has a long history with processing methods including pulverization, the fire burnt, calcined quenching, calcined vinegar, vinegar boiling, calcined brine, etc. At present, China mainly use the method of calcining. Summerizing the predecessors＇ experience will provide beneficial reference to further study of Arcae Concha.