阻塞性睡眠呼吸暂停与肿瘤的研究进展

Obstructive sleep apnea and cancer: a review

近年来,许多流行病学研究发现阻塞性睡眠呼吸暂停(OSA)和肿瘤患病率存在相关性。大量动物实验和临床研究进一步证实OSA与肿瘤发生和进展相关,目前研究表明其机制主要涉及以下方面:氧化应激、炎症反应、交感神经兴奋性增高、免疫功能异常、外泌体、低氧诱导因子(HIF)等。

Several studies have recently demonstrated that patients with obstructive sleep apnea（ OSA） have a high prevalence of cancer and cancer-related mortality. A large number of animal experiments and clinical studies have further confirmed that OSA can be involved in tumorigenesis and progression. The mechanism may involve oxidative stress,systemic inflammation,sympathetic outflow,immune dysfunction,exosomes,hypoxia-inducible factor（ HIF）,and so on.