喜炎平注射液、磷酸奥司他韦颗粒、蓝芩口服液治疗流感样病例的临床效果研究

Study of Clinical Effect of Xiyanping Injection,Oseltamivir Phosphate Granules and Lanqin Oral Liquid in Treatment of Influenza-like Illness

目的:比较喜炎平注射液、磷酸奥司他韦颗粒及蓝芩口服液在流感样病例早期治疗中的临床效果。方法:选取95例早期就诊的流感样患者,随机分为三组,喜炎平注射液组30例,静脉滴注,250 mg/次,1次/d,共3 d;磷酸奥司他韦颗粒组31例,口服,75 mg/次,2次/d,共3 d;蓝芩口服液组34例,口服,20mL/次,3次/d,共3 d。比较三组患者治疗效果和不良反应发生情况。结果:喜炎平注射液组的发热、头痛、咳嗽缓解时间均明显短于磷酸奥司他韦颗粒组与蓝芩口服液组(P<0.05),磷酸奥司他韦颗粒组与蓝芩口服液组比较,差异均无统计学意义(P>0.05);喜炎平注射液组肌痛缓解时间明显短于蓝芩口服液组(P<0.05),与磷酸奥司他韦颗粒组比较,差异无统计学意义(P>0.05);蓝芩口服液组咽痛缓解时间最短,与其他两组比较差异均有统计学意义(P<0.05)。三组卡他症状的缓解时间两两比较,差异均无统计学意义(P>0.05)。95例患者中有8例发生不良反应,症状轻,各组间不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:喜炎平注射液的早期使用能明显缩短流感样症状发热、头痛、咳嗽的持续时间,减轻症状的严重程度,适合在临床中推广使用。

Objective： To compare the effects of Xiyanping Injection, Oseltamivir Phosphate Granules and Lanqin Oral Liquid in treating influenza-like illness （ILI ） .Method： A total of 95 patients were divided into three randomized groups.The Xiyanping Injection group including 30 cases were given 250 mg/time, 1 time/d, a total of 3 d, intravenous drip.The Oseltamivir Phosphate Granules group including 31 cases were given 75 mg/time, 2 times/d, for 3 d, oral.The Lanqin Oral Liquid group including 34 eases were given 20 mL/time, 3 times/d, for 3 days, oral.The effect and adverse reactions were compared between the three groups.Result： The fever, headache, cough relief time of Xiyanping Injection group, were significantly shorter than those in Osehamivir Phosphate Granules group and Lanqin Oral Liquid group （ P〈0.05 ）, the Oseltamivir Phosphate Granules compared with Lanqin Oral Liquid group, there were no significant differences （ P〉0.05 ） ; the muscle pain relief time of Xiyanping Injection group was significantly shorter than that in Lanqin Oral Liquid group （ P〈0.05 ）, compared with Oseltamivir Phosphate Granules group, the difference was not statistically significant （ P〉0.05 ） ; the angina relief time of Lanqin Oral Liquid group was the shortest, compared with the other two groups were statistically significant （ P〈0.05 ） .The differences of the catarrh relief time between the three groups were no significant （ P〉0.05 ） .95 patients with adverse reactions occurred in 8 cases, mild symptoms, there were no significant differences in the incidence of adverse reactions between the three groups （P〉0.05） .Conclusion： The early use of Xiyanping Injection can significantly reduce the flu like symptoms of fever, headache, cough duration, reduce the severity of symptoms, suitable for use in clinical.