骨科钛板表面TiO_2纳米管阵列/MCM-41分子筛复合型药物载体的构建及负载阿仑磷酸钠缓释性能研究

Construction of TiO_2 nanotube array/MCM-41 molecular sieves compound drug carrier on orthopaedic titanium plate surface and study on sustained-release performance of alendronate sodium supported on the composites

目的构建一种骨科钛板表面TiO2纳米管阵列/MCM-41分子筛复合型药物载体,考察阿仑膦酸钠负载在复合体上的缓释性能。方法通过溶胶-凝胶法能获得稳定的TiO2纳米管阵列/MCM-41分子筛复合型药物载体,利用X射线衍射、扫描电镜(SEM)、比表面积仪表征了TiO2纳米管阵列/MCM-41分子筛复合型药物载体的形貌和比表面积,通过柱前衍生化HPLC法测定阿仑膦酸钠(ALN)负载在复合体上的缓释性能。结果 TiO2纳米管阵列/MCM-41分子筛复合型药物载体的比表面积为151.27m2/g,孔容为0.232cm3/g,负载在该复合载体中的ALN在1~4d仅释放了65.44%,8d后的释放率达到85.03%。结论骨科钛板表面TiO2纳米管阵列/MCM-41分子筛复合型药物载体较单纯的TiO2纳米管阵列具有更大的比表面积,能够有效提高骨科钛板表面的药物担载量,同时提高ALN在骨科钛板表面的缓释性能。

Objective To construct TiO2 nanotube array/MCM-41 molecular sieves compound drug carrier on the orthopaedic titanium plate surface,and to inspect the sustained-release performance of the alendronate sodium supported on the composites.Methods The stable TiO2 nanotube array/MCM-41 molecular sieves compound drug carrier was constructed by the solgel method.The morphology and BET surface area of the composites were characterized by using X-ray diffraction（XRD）,scanning electron microscope（SEM）and specific surface area analyzer.The sustained-release performance of the Allen phosphonic acid sodium supported on the composites was determined by the HPLC with pre-column derivatization.Results The specific surface area of the composite material was 151.27m^2/g,the entrance was 0.232cm^3/g,Allen phosphonic acid sodium（ALN）supported on the composite carrier released only 65.44% between one day and four days,and release rate reached 85.03% on the eighth day.Conclusion The TiO2 nanotube array/MCM-41 molecular sieves compound drug carrier on the orthopaedic titanium plate surface has larger specific surface area than the TiO2 nanotube array carrier on the orthopaedic titanium plate surface.It can effectively improve the orthopaedic drugs carry supported on the surface of the titanium plate,at the same time,improve Allen phosphonic acid sodium slow-release performance on the surface of the titanium plate.