原发性系统型间变性大细胞淋巴瘤1例

A Case of Primary Systemic Anaplastic Large Cell Lymphoma

患者男,52岁。颈部红斑1月余伴颈部多发淋巴结肿大。皮损组织病理示:真皮及表皮浅层水肿,弹力纤维撕裂,并可见较多急、慢性炎细胞浸润;皮损免疫组织化学染色:CD30(-),ALK(-),EMA(-),Ki-67(+<5%)。颈部淋巴结病理诊断:间变性大细胞淋巴瘤;淋巴结免疫组织化学染色瘤细胞:CD2(+),CD3(+),CD30(+),ALK(+),CD4(2+),CD5(2+),CD43(2+),EMA(3+),Ki-67(+>80%)。诊断:原发性系统型间变性大细胞淋巴瘤。

A 52yearold male presented with red plaques on his right neck for 1 monthHistopathological examination of the skin lesions showed severe edema in the upper and middle dermal layers, the tearing of elastic fibers, and lots of inflammatory cells infiltration of dermisThe immunohistochemisty of skin lesions showed CD30（-）, ALK（-）,EMA（-）,Ki67（＋〈5%）The cervical lymph nodes were histologically diagnosed as anaplastic large cell lymphomaThe immunohistochemistry of tumor cells showed CD2（＋）, CD3（＋）,CD30（＋）, ALK（＋）,CD4（2＋）, CD5（2＋）,CD43（2＋）,EMA（3＋）, Ki67（＋〉80%）The diagnosis of primary systemic anaplastic large cell lymphoma was made