基底细胞癌的共聚焦激光扫描显微镜特征初探

Preliminary Morphologic Features of Basal Cell Carcinoma under Confocal Laser Scanning Microscopy

目的探讨基底细胞癌的共聚焦激光扫描显微镜影像学特征。方法应用共聚焦激光扫描显微镜分析14例基底细胞癌患者皮损部位的影像学特征。结果共聚焦激光扫描显微镜检测发现,13例基底细胞癌患者可见到表皮层异常,14例患者均可见单一形态的拉长细胞核出现,10例患者可见肿瘤细胞团块、细胞核极化及组织间隙,7例患者可见明显的炎性细胞浸润,8例患者皮损表皮及真表皮交界处可见大量色素团块、树突状细胞,真皮内血管增加,管腔增粗,并可见白细胞沿管壁快速流动。结论共聚焦激光扫描显微镜作为一项无创新技术,可以用于基底细胞癌的辅助诊断。

Objcetive To investigate the preliminary morphologic features of basal cell carcinoma （BCC） under confo- eal laser scanning microscopy （CLSM）. Methods The lesions of fourteen patients with basal cell carcinoma were examined by CLSM. Results Under CLSM, there was pleomorphic epidermis found in thirteen BCC cases; elongated monomorphie nuclei found in all BCC cases. Meanwhile, nodular masses, polarized nuclei and interstitial spaces were shown in ten BCC cases. Significant inflammatory cell infiltrates were observed in seven BCC cases. Interestingly, there were a lot of pigmented aggregates and dendritic cells found in epider- mis and dermo-epidermal junction in eight BCC cases, accompanied by increased vascularity, enlarged ves- sel lumen and rolling leukocytes. Conclusion CLSM can offer an alternative technique for noninvasive diag- nosis of basal cell carcinoma in vivo.