冠心病合并2型糖尿病患者幽门螺杆菌感染状况与踝臂指数及脉搏波传导速度相关性研究

Coronary heart disease with type 2 diabetes mellitus patients with helicobacter pylori infection status and ankle-brachial index and brachial-ankle pulse wave velocity correlation studies

目的:探讨冠心病合并2型糖尿病患者幽门螺杆菌(HP)感染状况与踝臂指数(ABI)及脉搏波传导速度(BaPWV)的相关性,分析HP感染对冠心病合并糖尿病患者动脉硬化的影响。方法:选取冠心病合并2型糖尿病患者200例,采用C14尿素呼气试验检测HP感染状况及严重程度,测定ABI及BaPWV。结果:HP感染阳性137例,感染率68.50%,其中轻度感染、重度感染者分别为78例、59例,感染率分别为39.00%、29.50%;左侧、右侧ABI在HP感染患者与无HP感染患者中比较差异无统计学意义,HP感染患者左侧、右侧BaPWV分别为(1719.20±325.85)cm/s、(1722.94±330.55)cm/s,分别高于无HP感染患者(1573.64±410.75)cm/s、(1584.59±394.16)cm/s,差异均有统计学意义(P<0.05);重度HP感染患者左侧、右侧ABI分别为(1.04±0.10)、(1.03±0.11),均低于轻度HP感染患者(1.08±0.11)、(1.08±0.13),左侧、右侧BaPW重度HP感染患者为(1913.60±365.22)cm/s、(1901.48±360.53)cm/s,分别高于轻度HP感染患者(1641.27±356.80)cm/s、(1621.19±378.51)cm/s,差异均有统计学意义(P<0.05);直线相关分析显示HP感染与ABI间无相关性(P>0.05),与BaPWV间有正相关性(P<0.05)。结论:冠心病合并2型糖尿病患者HP感染率较高,HP感染与BaPWV的升高有密切相关性,HP感染可能参与了冠心病合并2型糖尿病患者动脉硬化的发生。

Objective：To investigate the coronary heart disease with type 2 diabetes mellitus patients with he-licobacter pylori （HP） infection status and ankle - brachial index （ABI） and brachial-ankle pulse wave velocity （BaP-WV） correlation, Analysis of HP infection on the hardening of the arteries of patients with coronary by heart disease complicated with 2 diabetes mellitus patients. Methods ： Choosed 200 patients with coronary heart disease with type 2 diabetes mellitus,the C14 urea breath test to detect HP infection status and severity, ABI and BaPWV measure-ment. Results：HP infection were 137 cases, infection rate were 68. 50% , among them 78 cases of mild infection, se-vere infection 59 cases, infection rates were 39. 00% and 29. 50% ;The left and right ABI, patients with HP infection in patients with and without HP infection patients,there was no statistically significant difference comparison,the left and the right BaPWV： HP infection patients were（1719. 20 ± 325. 85） cm/s and（1722. 94 ± 330. 55） cm/s , without HP infection patients were（1573. 64± 410. 75）cm/s and（1584. 59 ± 394. 16）cm/s,compare the difference was statis-tically significant （P〈0 . 05） ; the left and the right ABI： severe infection patients were（1. 04 ± 0. 10）and（1. 03 ± 0.11） ,mild infection patients were（1. 08 ±0. 11）and（1. 08± 0. 13） ,the left and the right BaPWV： severe infection pa-tients were（1913. 60 ± 365. 22）cm/s and（1901. 48 ± 360. 53）cm/s,mild infection patients were（1641. 27± 356. 80） cm/s and（1621. 19±378. 51）cm/s,compare the difference was statistically significant （P〈 0. 05） ;Linear correlation between HP infection and ABI no correlation （P〉 0. 05） , and there was positive correlation between BaPWV （P〈 0. 05）. Conclusion：Coronary heart disease with type 2 diabetes mellitus patients with HP infection rate were higher, HP infection is closely related to the rise of BaPWV correlation, HP infection may be involved in the occurrence of coronary heart disease with type 2 diabetes mellitus patients with atherosclerosis.