肺癌组织环指蛋白RNF38的表达及其临床意义

Expression of RNF38 in lung cancer and its clinical significance

目的:探讨肺癌组织环指蛋白RNF38的表达及其与肺癌临床病理特征及预后的关系。方法:采用组织芯片检测208例肺癌组织中RNF38蛋白表达,分析其与肺癌患者临床病理特征及预后的关系。结果:肺癌组织RNF38表达高于癌旁正常肺组织。不同肿瘤大小(P=0.000 2)、不同肿瘤分期(P=0.011)、有无淋巴结转移(P=0.000 04)及不同肿瘤类型(P=0.030)患者肺癌组织RNF38蛋白表达差异有统计学意义。RNF38高表达预示肺癌患者总生存率低。单因素分析显示RNF38表达与肺癌患者预后相关。结论:RNF38高表达与肺癌的恶性表型及不良预后相关。

Objective：To investigate the expression of RNF38 in lung cancer,and its correlationship with clinicopathologic feature and prognosis.Methods：Tissue microarray was used to detect the level of RNF38 in 208 lung cancer patients,then its correlationship with clinicopathologic feature and prognosis was analyzed.Results：RNF38 expression was higher in lung cancer tissues compared with the corresponding adjacent normal lung tissues.High level of RNF38 was related significantly to tumor size （P= 0.0002）,tumor stage （P= 0.011）,lymph node metastasis （P= 0.00004）and histological type （P= 0.030 ）.High level of RNF38 indicates low overall survival rate.Single factor analysis showed that RNF38 expression was related to lung cancer patients＇prognosis.Conclusions：The high level of RNF38 could be a new marker in predicting the prognosis of lung cancer.