反复呼吸道感染(RRI)患儿血清25-羟维生素D_3[25-(OH)D_3]及免疫水平研究

Study on Serum 25-hydroxyvitamin D_3[25-(OH) D_3] and Immune Level in Children with Recurrent Respiratory Tract Infection(RRI)

目的:分析反复呼吸道感染(RRI)患儿血清25-羟维生素D_3[25-(OH)D_3]表达水平、免疫水平变化的临床意义。方法:纳入我院2015年3月~2016年5月期间收治的38例反复呼吸道感染患儿(研究组)和同期来我院接受健康体检的38例健康儿童(对照组)作为研究对象,检测两组研究对象血清25-羟维生素D_3、血清免疫球蛋白IgG、IgM、IgA表达水平。结果:研究组患儿血清25-羟维生素D_3缺乏率为50.00%,高于对照组健康儿童的10.53%,血清免疫球蛋白IgG、IgM、IgA表达水平均低于对照组健康儿童,差异均具有统计学意义(P<0.05)。结论:反复呼吸道感染的发生与患儿体内缺乏25-羟维生素D_3、免疫水平降低存在明显相关性,血清25-羟维生素D_3水平、免疫水平变化可用于评估反复呼吸道感染患儿病情变化情况。

Objective：To analyze the clinical significance of serum 25-hydroxyvitamin D3[25-（OH） D3]expression and immune level in children with recurrent respiratory tract infection（RRI）.Methods：Thirty-eight children with recurrent respiratory tract infection（study group） and 38 healthy children（control group） from our hospital from March 2015 to May 2016 were enrolled in this study.The levels of serum 25-hydroxyvitamin D3,serum immunoglobulin IgG,IgM and IgA in the two groups.Results：The serum 25-hydroxyvitamin D3 deficiency rate in the study group was 50.00%,10.53%higher than that in healthy children.The serum immunoglobulin IgG,IgM and IgA levels were lower in the study group than those in the control group,the difference was statistically significant（P〈0.05）.Conclusion：The occurrence of recurrent respiratory tract infection is closely related to the deficiency of 25-hydroxyvitamin D3 and the decrease of immune level in children.Serum levels of 25-（OH） D3 and changes in immune status can be used to assess the condition of children with recurrent respiratory tract infection changes.