阿维A胶囊联合紫外线治疗寻常型银屑病的疗效及对T淋巴细胞免疫功能的影响

Effect of Avi A Capsule Combined with Ultraviolet Irradiation in the Treatment of Psoriasis Vulgaris and Its Influence on the Immune Function of T Lymphocytes

目的:探讨阿维A胶囊联合紫外线治疗寻常型银屑病的疗效及对T淋巴细胞免疫功能的影响。方法:按照随机化原则,将120例寻常型银屑病患者分为观察组60例、对照组60例。观察组给予口服阿维A胶囊并联合窄谱中波紫外线治疗;对照组仅给予口服阿维A胶囊治疗,治疗8周后比较分析两组患者的临床疗效以及T淋巴细胞的免疫功能。结果:观察组与对照组总有效率分别为95.0%、83.3%,前者总有效率较后者高(H=3.684,P<0.05);观察组与对照组患者治疗8周后CD4^+水平均较治疗前增加,但前者患者治疗后CD4^+水平明显高于后者(P<0.05);治疗8周后,对于CD8^+水平,两组患者均较治疗前降低,但前者患者明显低于后者(P<0.05)。结论:对于寻常型银屑病患者,口服阿维A胶囊与窄谱中波紫外线光疗法均能通过改变他们体内T淋巴细胞的免疫失衡状态而发挥治疗作用,两者联合使用的治疗效果更佳,且不良反应少,临床应用价值高。

Objective：To study curative effect and influence on psoriasis vulgaris t lymphocyte immune function of narrow-band UVB combined with Avi A.Methods：120 cases psoriasis vulgaris patients were randomly divided into observation group and control group,each group had 60 cases,the observation group was given narrow-band UVB combined with Avi A treatment;the control group was only given Avi A.After treating 8 weeks,comparing two groups patients clinical efficacy and immune function of T lymphocytes.Results：Observation group total effective rate was 95.0%,the control group total effective rate was 83.3%,the former＇total effective rate was higher than the latter（H = 3.684,P〈0.05）.After treating 8 weeks,observation group and control group treatment levels of CD4^＋ were higher,the former patients CD4^＋ level obviously was higher than the latter patients（P〈0.05）;Observation group and control group patients CD8^＋ levels were reduced,the former patients CD8^＋ level was significantly lower than the latter patients（P〈0.05）.Conclusion：Narrowband UVB and Avi A therapy both can play A role by changing T lymphocyte immune imbalance of psoriasis vulgaris patients,the effect of combination of both treatment is better,and adverse reaction is less,having high clinical value.