夜间不明原因猝死综合征和阻塞性睡眠呼吸暂停低通气综合征关系的研究进展

Research Progress of the Relationship between SUNDS and OSAHS

夜间不明原因猝死综合征一直是法医学研究的难点,近年来分子遗传学的发展促进了其病因学研究,但仍有大部分案例病因不明。睡眠呼吸暂停综合征是一种常见的睡眠障碍性疾病,其中以阻塞性睡眠呼吸暂停低通气综合征最为常见。近年来,国内外研究表明阻塞性睡眠呼吸暂停低通气综合征与心血管疾病的发生密切相关,可以导致心律失常甚至引起猝死。本文主要综述了夜间不明原因猝死综合征与阻塞性睡眠呼吸暂停低通气综合征之间的关系,从而为不明原因猝死的发病机制提供新的思路。

Sudden unexplained nocturnal death syndrome（SUNDS） is always a difficulty in forensic medicine researches. Although the development of molecular genetics promotes the etiologic study of SUNDS, the pathogenesis of most such cases is still unclear. Sleep apnea syndrome（SAS） is one of the common forms of sleep disorders, and obstructive sleep apnea hypopnea syndrome（OSAHS） is the most common. In recent years, some domestic and international researches show that OSAHS is related to the development of cardiovascular disease, which may cause cardiac arrhythmia, even sudden death.This article reviews the relationship between SUNDS and OSAHS and aims to provide new ideas for the pathogenesis of SUNDS.