二甲双胍治疗妊娠合并多囊卵巢综合征和妊娠期糖尿病的有效性及安全性分析

Analysis of Effectiveness and Safety of Melbine in Treatment of Pregnancy Combined with Stein-Leventhal Syndrome and Gestational Diabetes

目的分析在妊娠期糖尿病与娠娠合并多囊卵巢综合征治疗中实行二甲双胍治疗的安全性以及有效性。方法选取该院妇产科自2013年1月—2016年1月期间收治的60例产妇,正常妊娠产妇作为A组,妊娠期糖尿病产妇作为B组,妊娠合并多囊卵巢综合征产妇作为C组,B组与C组患者入院后均实行二甲双胍治疗,对比分析3组患者妊娠不良反应结局、治疗效果以及指标变化情况。结果 A组与B组、C组患者总有效率、血糖、胰岛素抵抗、甘油三酯、胆固醇等指标之间,差异有统计学意义(P<0.05);A组与B组之间不良反应差异有统计学意义(P<0.05),但是A组与C组之间不良反应差异无统计学意义(P>0.05)。结论对于妊娠期糖尿病以及妊娠合并多囊卵巢综合征的治疗中应用二甲双胍均具有一定效果,多囊卵巢综合征可能会增加产妇发生糖尿病的几率,但是二甲双胍可以提升治疗安全性以及有效性。

Objective To analyze the effectiveness and safety of melbine in treatment of pregnancy combined with SteinLeventhal syndrome and gestational diabetes. Methods 60 cases of delivery women admitted and treated from January 2013 to January 2016 were selected and divided into three groups, the group A were the normal delivery women, the group B were the gestational diabetes group, and the group C were the pregnancy combined with Stein-Leventhal syndrome, and after admission, the group B and group C were treated with melbine, and the adverse reaction outcome, treatment effect and index changes of the three groups were compared and analyzed. Results There were obvious differences in the total effective rate, blood sugar, insulin resistance, triglyceride and cholesterol between the three groups, and the differences had statistical significance（P〈0.05）, and there was obvious difference in the adverse reaction between the group A and group B（P〈0.05）,but the difference in the adverse reaction between the group A and group C was not obvious and the difference had no statistical significance（P〈0.05）. Conclusion Melbine in treatment of pregnancy combined with stein-leventhal syndrome and gestational diabetes has a certain effect, and the Stein-Leventhal syndrome may increase the occurrence probability of diabetes of the delivery women but melbine can improve the treatment safety and effectiveness.