DNA倍体分析在CINⅡ以上宫颈病变筛查中的应用价值Meta分析

Meta analysis on the value of cervical lesion screening of DNA heteroploid in screening of CINⅡand above cervical lesions

目的分析DNA倍体检测在CINⅡ级以上宫颈病变筛查中的应用价值。方法检索2015年1月至12月被万方数据库收录的关于DNA倍体分析的文献。结果通过对筛选的4篇文献结果进行分析汇总,发现DNA倍体分析在筛查CINⅡ级以上宫颈癌病变中的敏感度为71%~91%,特异性度62%~90%。结论 DNA倍体分析敏感性高,可作为新的筛查手段应用于临床,与其他筛查方法联合应用可提高CIN的检出率,值得在临床推广。

Objective To study the value of DNA ploidy analysis in screening CINⅡand above cervical lesions. Methods By searching the related literatures included from Wanfang database during January to December in 2015,and to learn about the sensitivity and specificity of DNA ploidy analysis. Results The sensitivity and specificity of DNA ploidy analysis in screening CINⅡ ＋ cervical lesions are 71%-91% and62%-90% respectively. Conclusion With high sensitivity,DNA ploidy analysis can be applied in clinical practice as a novel screening method. When it combined with other methods,DNA ploidy analysis can increase the detection rate of CIN in cervical lesions and it should be widely used in clinical practice.