ERK通路蛋白、ANXA2及FOXJ1蛋白表达与胃癌患者临床分期及预后的相关性研究

The relationship of serum ERK signaling pathway proteins and ANXA2,FOXJ1 with the clinical stage and prognosis of gastric cancer patients

目的对细胞外调节蛋白激酶(ERK)通路蛋白、膜联蛋白A2(ANXA2)及叉头框蛋白J1(FOXJ1)蛋白表达与胃癌患者临床分期及预后的相关性进行研究,为临床诊断和治疗提供参考。方法对2011年3月至2015年12月期间诊治的180例胃癌患者进行研究,其中0期38例,Ⅰ期者36例,Ⅱ期30例,Ⅲ期37例,Ⅳ期39例。同期健康体检者30例为对照组。分析各研究对象血清ANXA2及FOXJ1蛋白表达与胃癌患者临床分期及预后的相关性。结果与对照组比较,胃癌组Ras、Raf、MEK、ERK1/2、ANXA2和ANXA4、FOXJ1及TAP1蛋白均明显升高,且随着胃癌临床分期的增加,上述蛋白的表达明显增强(P<0.05);ANXA2及FOXJ1蛋白与胃癌患者临床预后有密切的相关性,且随着ANXA2蛋白表达的增强患者的预后变差。结论 ERK信号通路蛋白、ANXA2及FOXJ1蛋白表达与胃癌患者临床分期及预后有明显的相关性。

Objective The present research aimed to explore the relationship of serum ERK signaling pathway proteins and ANXA2,FOXJ1 with the clinical stage and prognosis of gastric cancer patients. Methods 180 cases of gastric cancer patients in our department from Mar2011 to Dec 2015 were enrolled in this part. 38 cases in stage 0,36 cases in stage Ⅰ,30 cases in stage Ⅱ,37 cases in stage Ⅲ and 39 cases in stage Ⅳ. The relationship of serum ERK signaling pathway proteins and ANXA2,FOXJ1 with the clinical stage and prognosis in gastric cancer patients were analyzed. Results Compared with the control group,Ras,Raf,MEK,ERK1 /2,ANXA2,ANXA4,FOXJ1 and TAP1 protein were significantly increased in gastric cancer group. And the expression of these proteins was enhanced with the clinical stage of gastric cancer.ANXA2 and FOXJ1 protein were closely related with the clinical prognosis,and with the enhancement of ANXA2 protein expression,the prognosis was poor. Conclusion ERK signaling pathway proteins and the expression of ANXA2,FOXJ1 have a close relationship with the clinical stage and prognosis of gastric cancer patients.