催化非脱羧克莱森缩合反应的新型酮酶

Novel Ketosynthases of Catalyzing the Non-decarboxylative Claisen Condensation

酮酶对于多种生物代谢途径至关重要,且对碳碳键的生物合成起关键作用。目前,对脱羧的克莱森缩合反应研究较为深入,而催化非脱羧克莱森缩合反应的酮酶的研究工作相对较少。最近,在这方面的研究取得了一些新的进展。本文论述了与之相关的新型酮酶的酶学特性、结构基础、催化机制以及应用前景。

Ketosynthases are essential for several metabolic pathways and play a vital function in biosynthesis of carbon-carbon bond.Until now,decarboxylative Claisen reaction has been intensitively studied,while the research of ketosynthases which catalyzed the non-decarboxylative Claisen condensations is relatively scarce.Recently,some new progresses have been made in this field.In this paper,novel ketosynthases have been discussed including their enzymatic characteristics,structure basis,catalytic mechanism and application prospect.