成纤维细胞生长因子23多态性与小儿川崎病患者心血管病变易感性的关系

Fibroblast growth factor 23 gene polymorphism in children with Kawasaki syndrome and susceptibility to cardiac abnormalities

目的探讨川崎病患儿成纤维细胞生长因子(FGF)-23基因多态性、血清表达水平及对心脏病易感性的影响。方法选取2013年1月~2015年1月我院收治的90例川崎病患儿,检测90例患儿的FGF-23基因内含子多态性及心脏病的发生情况,根据患儿FGF-23的不同基因型将其分成FGF-23基因多态性组和FGF-23基因野生型组,比较两组患儿的血清FGF-23水平、血清相关指标及心脏病变易感性。结果本研究90例川崎病患儿中,FGF-23基因野生性组患儿64例,所占比例为71%,FGF-23基因多态性组患儿26例,所占比例为29%;FGF-23基因多态性组男性比例及血清FGF-23水平[92%,(41±15)ng/L]显著高于对照组[62%,(11±13)ng/L,P<0.05];FGF-23基因多态性组患儿冠状动脉扩张、冠状动脉瘤以及心脏受累发生率均显著高于FGF-23基因野生性组(P<0.05);Logistic回归多因素分析发现血清FGF-23水平与川崎病患儿心血管病变的发生率显著相关(P<0.01)。结论 FGF-23基因多态性的川崎病患者血清FGF-23水平显著增高,且冠状动脉异常几率增大。

AIM To investigate genetic variations in the FGF-23 gene in children with Kawasaki syndrome and its association with serum FGF-23 levels and eventual development of cardiac abnormalities. METHODS Ninety children with Kawasaki disease （from January 2013 to January 2015） in our hospital were selected for this study and FGF-23 gene intron polymorphism and incidence of heart disease were examined. According to different genotypes of FGF-23, 90 cases were divided into FGF-23 gene polymorphism group and FGF-23 gene wild-type group.Serum FGF-23 level, serum-related indicators and susceptibility of heart attack were compared between groups. RESULTS Of the 90 cases, 64 cases had the FGF-23 wild-type genotype （71%） and 26 had the FGF-23 gene polymorphism （29%）. The proportion of males and serum FGF-23 levels in FGF-23 gene polymorphism group were significantly higher than those in FGF-23 wild-type gene group [92%, （41±15） pg/ml vs. 62%, （11±13） pg/ml; P〈0.05]. The incidence of coronary aneurysms or dilatation in the FGF-23 gene polymorphism group was significantly higher than in the wild-type FGF-23 gene group （P〈0.05）. CONCLUSION Serum FGF-23 levels of patients with Kawasaki disease and FGF-23 gene polymorphism are significantly increased and the risk of coronary artery abnormalities is increased.