晚期糖基化终末产物对心血管损伤的机制及防治策略

Underlying mechanisms and preventive strategies of advanced glycation end products in cardiovascular injury

晚期糖基化终末产物(advanced glycosylation end products,AGEs)是糖酮或醛基与蛋白、脂质、氨基酸的自由氨基经不可逆反应所形成的物质,是非酶糖基化反应的最终产物。研究发现在动脉硬化、心肌舒张异常及内皮功能紊乱等心血管疾病中都出现AGEs水平的增加,并且抑制AGEs的产生或作用具有心血管保护作用。因此,AGEs可以作为防治心血管疾病的一个潜在靶点。本文重点综述了AGEs的来源、心血管损伤机制及防治策略。

Advanced glycation end products （AGEs） are a complex group of compounds that are formed when reducing sugar or aldehyde reacts irreversibly in a non-enzymatic manner with free amino in proteins, lipoids or amino acids. Increased level of AGEs has been found in cardiovascular diseases such as arterial stiffening, myocardial relaxation abnormalities and endothelial dysfunction. Furthermore, accumulation of AGEs contributes to changes in the structure and function of cardiovascular system. Thus, it is possible to prevent or cure cardiovascular diseases by inhibition of AGEs. This review mainly summarizes the sources of AGEs, the underlying mechanisms in induction of cardiovascular injury and the preventive strategies.