体质量指数与结直肠癌预后的关系

The correlation between body mass index and prognosis of colorectal cancer

目的:探讨体质量指数与结直肠癌患者预后的关系。方法:回顾性分析2010年1月至2011年12月新疆医科大学附属肿瘤医院收治的353例行根治手术的结直肠癌患者临床病理资料。将患者分为低体重组(BMI<18.5kg/m^2)、正常体重组(18.5kg/m^2≤BMI<23kg/m^2)、超重组(23kg/m^2≤BMI<27.5kg/m^2)、肥胖组(BMI≥27.5kg/m^2)。比较四组临床因素,分析BMI与结直肠癌患者5年生存率的关系。结果:BMI与患者术前CA199有统计学差异(P=0.020),对5年生存率无显著影响(P=0.254)。民族、p T分期、术前放化疗、肿瘤分化程度均是结直肠癌独立预后因素(P<0.05)。结论:BMI对结直肠癌患者的预后无显著影响。

Objective：To explore the correlation between body mass index（ BMI） and prognosis of patients with colorectal cancer（ CRC）. Methods：Clinical data of 353 patients with colorectal cancer who underwent radical operation in the Affiliated Tumor Hospital of Xinjiang Medical University from January 2010 to December 2011 were analyzed retropectively. The patients were divided into low weight group（ BMI 18. 5kg / m^2）,normal weight group（ 18. 5kg/m^2≤BMI 23 kg / m^2）,overweight group（ 23 kg / m^2≤BMI 27. 5kg/m^2） and obese group（ BMI≥27. 5kg / m^2）. The clinicopathological factors were compared among these four groups and the correlation between BMI and 5- year survival rate of patients with colorectal cancer was analyzed. Rusults：There was statistically significant correlation between BMI and preoperative CA199 of patients（ P = 0. 020）. No statistically significant correlation was found between BMI and 5- year survival rate（ P = 0. 254）. Nationality,PT stage,preoperative chemoradiotherapy,tumor differentiation were significant independent risk factors（ P 0. 05）. Conclusion：There is no significant association between BMI and prognosis of patients with colorectal cancer.