雾化吸入特布他林和布地奈德联合服用小儿咳喘灵颗粒治疗小儿哮喘的临床效果研究

Clinical effect of inhalation of terbutaline and budesonide combined with oral Xiaoerkechuanling granules in the treatment of infantile asthma

目的：探讨雾化吸入特布他林和布地奈德联合小儿咳喘灵颗粒治疗小儿哮喘的临床疗效。方法选取96例罹患哮喘的患儿，采用随机数字表法分为对照组和观察组，两组均给予常规药物治疗，对照组在常规治疗的基础上雾化吸入硫酸特布他林雾化液和布地奈德混悬液；观察组在对照组的基础上加用小儿咳喘灵颗粒，两组均连续治疗7 d。观察两组的临床疗效、肺功能指标变化及不良反应。结果治疗后，观察组临床总有效率为93．80％，对照组临床总有效率为75．00％，两组差异有统计学意义（χ^2＝3．200，P 〈0.05）；观察组肺活量（FEV）、1秒用力呼气量（FEV1）、第1秒用力呼气量百分率（FEV ／FEV1）分别为（3．49±0．61）L、（2．54±0．47）L、（93．33±8．46）％，明显优于对照组的 FEV、FEV1、FEV ／FEV1[（2．79±0.52）L、（1.96±0.43）L、（75．98±5．84）％]，各指标差异有统计学意义（t ＝6．050、6．308、11．693，均 P 〈0.05）；观察组不良反应发生率为12．60％，对照组不良反应发生率为10．50％，两组差异无统计学意义（χ^2＝0．051，P 〉0.05）。结论雾化吸入特布他林和布地奈德联合小儿咳喘灵颗粒用于治疗小儿哮喘，可显著改善患儿的肺功能，提高临床疗效，且不良反应较少，具有临床推广价值。

Objective To investigate the clinical efficacy of inhalation of terbutaline,budesonide combined with Xiaoerkechuanling granules in the treatment of infantile asthma.Methods 96 children with asthma were selected and randomly divided to observation group and control group.The two groups were given routine drug treatment,the control group was given sulfate inhalation terbutaline atomization liquid and budesonide suspension on the basis of conventional treatment.The observation group was given Xiaoerkechuanling granules on the basis of the control group. The two groups were treated for 7 days.The clinical curative effect of the two groups,the changes of lung function and adverse reactions were observed.Results After treatment,the total effective rate in the observation group was 93.80%,which in the control group was 75.00%,the difference between the two groups was statistically significant （χ^2 =3.200,P 〈0.05）.The FEV1 ,FEV1 and FEV /FEV1 of the observation group were （3.49 ±0.61）L,（2.54 ± 0.47）L,（93.33 ±8.46）%,which were significantly better than those of the control group[（2.79 ±0.52）L,（1.96 ± 0.43）L,（75.98 ±5.8）%],the differences between the two groups were statistically significant（t =6.050,6.308, 11.693,all P 〈0.05）.The incidence rate of adverse reaction in the observation group was 12.60%,which in the control group was 10.50%,there was no statistically significant difference between the two groups （χ^2 =0.051,P 〉0.05 ）.Conclusion Inhalation of terbutaline,budesonide combined with Xiaoerkechuanling granules for the treatment of asthma in children can significantly improve the patients＆#39;pulmonary function,improve clinical curative effect,and it has less adverse reaction and great clinical value.