血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值与老年ST段抬高型心肌梗死的关系

Correlation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with ST-segment elevation myocardial infarction in elderly patients

目的研究中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与老年ST段抬高型心肌梗死(STEMI)及PCI术后短期主要不良心血管事件(MACE)的关系。方法选取接受PCI治疗的老年STEMI患者116例及健康体检者116例,分析NLR、PLR及其他主要临床生化指标与老年STEMI的关系,评估术前、术后NLR及PLR的变化对PCI术后MACE发生的预测价值。结果老年STEMI患者组高血压患病率、UA、LDL-C水平、WBC、NLR、PLR均明显高于对照组;而RBC、Hb则明显低于对照组,差异有统计学意义(P<0.05)。老年STEMI患者无MACE组NLR及PLR数值术后均较术前明显下降,差异有统计学意义(P<0.05),而老年STEMI患者合并MACE组NLR及PLR数值术前、术后无明显变化。结论 NLR及PLR是老年STEMI的独立危险因素,且与PCI术后的短期预后有关。

Objective To investigate the relationship of neutrophil to lymphocyte ratio（NLR） and platelet to lymphocyte ratio（PLR） with ST-segment elevation myocardial infarction（STEMI） and percutaneous coronary intervention（PCI） for the major adverse cardiovascular events（MACE） in elderly patients.Methods A total of 116 STEMI patients receiving PCI and 116 healthy controls were recruited.The correlation of NLR,PLR and clinical biochemical indicators with STEMI in elderly people was investigated.The predictive value of NLR and PLR for the incidence of MACE were explored before and after PCI.Results The prevalence rate of hypertension,levels of UA,LDL-C,WBC,NLR,PLR were significance higher in STEMI group than the control group,with the differences statistically significant（P〈0.05）.In STEMI without MACE group,the level of NLR and PLR were significantly lower after PCI than those before PCI,with the differences statistically significant（P〈0.05）.In STEMI with MACE group,the levels of NLR and PLR had no significant changes before and after PCI.Conclusion NLR and PLR are not only the independent risk factors for STEMI,but also closely related to STEMI after PCI.