人类免疫缺陷病毒合并结核感染者的免疫功能分析

Analysis of immune function in the HIV patients with tuberculosis

目的观察HIV合并结核感染者的免疫状况。方法利用结核感染T细胞检测法检测174例HIV感染患者和174例健康者的结核感染情况,并分析HIV合并结核感染患者的免疫状况。结果 HIV感染组结核阳性率为31.0%,对照组结核阳性率为1.7%,2组比较差异有统计学意义(χ2=54.57,P<0.01)。CD4/CD8比值≥0.71时HIV合并结核感染的阳性率为13.4%,CD4/CD8比值<0.71时HIV合并结核感染的阳性率为42.0%,2组比较差异有统计学意义(χ2=17.54,P<0.01)。CD4阳性T淋巴细胞计数≥200个/μl的有72例、CD4阳性T淋巴细胞计数为100个/μl^200个/μl的有45例、CD4阳性T淋巴细胞计数<100个/μl的有57例,3组结核感染率分别为6.9%、26.7%、65.0%,差异有统计学意义(χ2=52.24,P<0.01)。结论 HIV合并结核感染患者免疫功能降低,CD4 T淋巴细胞数目减少,且CD4 T淋巴细胞普遍<200个/μl。

Objective To evaluate the immune status of the HIV patients with tuberculosis.Methods The tuberculosis infection status of 174 HIV infection and the tuberculosis infection status of 174 cases of healthy persons were detected.The immune status of the HIV patients with tuberculosis were analyzed.Results The positive rate of tuberculosis in HIV infection group was31.0%,the positive rate of tuberculosis in the control group was 1.7%,and the difference between the two groups was statistically significant（χ^2= 54.57,P〈0.01）.The positive rate of HIV combined with tuberculosis infection was 13.4%,when the HIV patients with CD4/CD8 ratio was ≥0.71.The positive rate of HIV combined with tuberculosis infection was 42% when the HIV patients with CD4/CD8 ratio was 0.71,and the difference between the two groups was statistically significant（χ^2=17.54,P〈0.01）.The flow cytometry results showed 57 cases had CD4 T lymphocyte less than 100 c/μl,55 cases had100 c/μl-200 c/μl CD4 T lymphocyte,72 cases had more than 200 c/μl CD4 T lymphocyte among the HIV patients,and the infection rates of tuberculosis were 6.9%,26.7% and 65%,respectively,with the differences statistically significant（χ^2=52.24,P〈0.01）.Conclusion The immune function of the HIV patients with tuberculosis decreased,the levels of CD4 T lymphocyte decreases in HIV complicated with tuberculosis patients,which is often less than 200 c/μl.