妊娠晚期孕妇检测凝血四项、FDP、D-二聚体的临床意义

Clinical significance of four coagulation tests,FDP test,and D-dimer test in pregnant women during the third trimester of pregnancy

目的探讨妊娠晚期孕妇进行凝血四项、纤维蛋白(原)降解产物(FDP)及D-二聚体检测的临床价值。方法选取晚期妊娠孕妇180例作为观察组,另外选取健康体检的非妊娠妇女180例作为对照组。采用全自动血凝仪对两组凝血四项(PT、APTT、FIB、TT)、FDP及D-二聚体水平进行检测。结果观察组的PT、APTT、TT检测水平方面与对照组相比均明显降低(P<0.05);观察组的FIB、FDP及D-二聚体水平与对照组比较均明显提高(P<0.05)。结论与正常非妊娠妇女相比,妊娠晚期妇女体内血液处于高凝状态,为最大程度地降低临床产科并发症的发生,应做好及时抢救的准备,临床上应对分娩前孕妇进行凝血功能的动态监测。

Objective To explore the clinical significance of four coagulation tests, fibrin degradation product （FDP） test, and D-dimer test in pregnant women during the third trimester of pregnancy. Methods A total of 180 pregnant women during the third trimester of pregnancy were selected as observation group, 180 non-pregnant women after healthy physical examination were selected as control group. Automatic blood coagulation analyzer was used to conduct four coagulation tests [ prothrombin time （PT）, activated partial thromboplastin time （APTT）, fibrinogen （FIB）, thrombin time （TT） ], FDP test, and D-dimer test. Results PT, APTT , and Tr in observation group were statistically significantly lower than those in control group （P〈0. 05） ; FIB, FDP, and D-dimer levels in observation group were statistically significantly higher than those in control group （P〈0. 05） . Conclusion Compared with normal non-pregnant women, the pregnant women during the third trimester of pregnancy are in high coagulation state, to furthest reduce clinical obstetric complications, timely rescue should be carried out, dynamic monitoring of blood coagulation function should be conducted in the pregnant women before delivery.