原发性遗尿儿童与非遗尿儿童go/no-go联想任务执行结果对比研究

A comparative study of go/no-go association task execution results in children with and without primary nocturnal enuresis

目的比较原发性遗尿儿童与非遗尿儿童go/no-go联想任务执行测试结果差异,探讨原发性遗尿儿童的反应抑制功能状况,为临床原发性遗尿儿童选择治疗方案提供参考。方法选择2015年1-8月在上海儿童医学中心发育行为儿科门诊就诊的、门诊资料完整的原发性遗尿儿童35例,设为观察组,选取同期健康体检的6~11岁儿童35例作为对照组。两组受试儿童均通过go/no-go联想任务执行测试对其反应抑制功能进行评估,对两组受试儿童go/no-go联想任务执行的go正确率、no-go正确率、go反应时间、no-go反应时间进行比较。结果两组受试儿童月龄、性别、体重、体质量指数(BMI)、遗尿频次、遗尿病程、语言智商得分、操作智商得分及总智商得分比较差异均无统计学意义(P>0.05)。两组受试儿童的go正确率、no-go正确率比较差异无统计学意义(P>0.05);但观察组儿童go反应时间、no-go反应时间较对照组儿童明显增加(P<0.05)。提示观察组儿童反应抑制功能存在缺陷。结论原发性遗尿儿童反应抑制功能较正常儿童存在缺陷,对原发性遗尿儿童进行反应抑制相关项目训练,可作为治疗遗尿的新靶点,结合其他治疗方案,可排除患儿因反应抑制功能缺陷而导致的药物及行为方式训练治疗复发率高、疗效不稳定的缺点,具有较高的临床价值。

Objective To compare go/no-go association task execution results between children with primary nocturnal enuresis and children without primary nocturnal enuresis, explore response inhibition function of children with primary nocturnal enuresis, provide reference for choosing treatment options. Methods Thirty-five children with primary nocturnal enuresis with intact data were selected from the hospital from January to August in 2015 as observation group, 35 children receiving healthy physical examination in the hospital during the same period were selected as control group. Response inhibition function of the children in the two groups were evaluated by go/no-go association task. The correct rates of go and no-go, the reaction time of go and no-go in the two groups were compared. Results There was no statistically significant difference in age, gender, weight, body mass index （ BMI）, frequency and duration time ofenuresis, language IQ, operation IQ, and total IQ between the two groups （ P〉0. 05 ） . There was no statistically significant difference in correct rates of go and no- go between the two groups （ P〉0. 05 ） . The reaction time of go and no-go in observation group was statistically significantly longer than that in control group （P 〈 0. 05 ）, which indicated that response inhibition function of the children in observation group was deficient. Conclusion Response inhibition function of children with primary nocturnal enuresis is deficient, related project training can be used as a new target in treatment of children with primary nocturnal enuresis. Combining with other therapies, the method can eliminate the disadvantages of drug and behavioral training caused by deficient response inhibition function, such as high recurrence rate and unstable effect, which has high clinical value.