树突状细胞-细胞因子激活的杀伤细胞免疫疗法与化疗联合治疗消化道肿瘤的临床疗效

Efficacy of DC-CIK combined with chemotherapy in treating gastrointestinal tumors

目的探讨树突状细胞-细胞因子激活的杀伤细胞免疫疗法(DC-CIK)与化疗联合治疗消化道肿瘤的临床疗效与安全性。方法选取2013年1月至2015年1月间大连市中心医院收治的116例晚期消化道肿瘤患者,采用随机数字表法分为研究组与对照组,每组58例。研究组患者在对照组化疗疗法基础上采用DC-CIK治疗,对照组患者单纯采用奥沙利铂、氟尿嘧啶和甲酰四氢叶酸(FOLFOX方案)化疗治疗。结果研究组患者有效率为60.3%,高于对照组的41.4%,两组比较,差异有统计学意义(P<0.05)。研究组患者免疫功能指标CD+4与CD+3均高于对照组,CD+8低于对照组,两组比较,差异均有统计学意义(均P<0.05)。两组患者药物不良反应比较,差异无统计学意义(P>0.05)。随访1年,研究组患者无进展生存率为25.9%和总生存率为34.5%,高于对照组的17.2%和25.9%,差异均有统计学意义(均P<0.05)。结论 DC-CIK与化疗联合治疗消化道肿瘤,可有效提高患者免疫功能,强化化疗敏感性,保证治疗效果,延长生存周期,适于临床推广。

Objective To investigate the efficacy and safety of cytokine-induced killer cells-dendritic cell（ DC-CIK） immunotherapy combined with chemotherapy in the treatment of gastrointestinal cancer. Methods Select 116 patients with advanced gastrointestinal cancer treated at The Municipal Central Hospital of Dalian from January 2013 to January 2015. Using random number table,these patients were divided into a study group and a control group and with 58 patients in each group. Patients in the control group received oxaliplatin,fluorouracil and leucovorin（ FOLFOX） chemotherapy alone and patients in the study group received DC-CIK maintenance treatment on the basis of FOLFOX. Results After treatment,the efficacy rate was 60. 3% in the study group which was higher than 41. 4% of the control group（ P 0. 05）. The indexes of immune function was higher and CD8~＋was lower in the study group than in the control group（ P 0. 05）. There was no significant difference in adverse drug reactions between the two groups（ P 0. 05）. After the follow up of 1 years,the progression free survival rate was 25. 9% and the overall survival rate was 34. 5% for the study group,which was higher than 17. 2% and 25. 9% of the control group respectively（ P 0. 05）. Conclusion DC-CIK combined with chemotherapy in the treatment of gastrointestinal cancer can effectively improve the immune function,strengthen the sensitivity of chemotherapy,ensure the treatment efficacy,prolong the survival period,which was suitable for promotion.