摘要
目的:制备吡罗昔康纳米结构脂质载体,并考察其体外透皮吸收性质。方法:采用热熔乳化超声-低温固化法制备吡罗昔康纳米结构脂质载体,并对其外观、微观形态、粒径分布、多分散系数(Pd I)、Zeta电位等理化性质进行评价;同时采用Franz扩散池法对其体外透皮吸收性质进行考察。结果:制备的吡罗昔康纳米结构脂质载体外观呈淡蓝色透明状液体,透射电镜可见呈圆整球状分布,平均粒径为(106.4±31.6)nm,Pd I为(0.217±0.07),Zeta电位为(-31.6±2.5)m V;吡罗昔康纳米结构脂质载体经12 h体外药物累积透皮量显著高于吡罗昔康溶液。结论:纳米结构脂质载体可以显著提高吡罗昔康的体外累积透皮量,有望成为吡罗昔康的新型局部给药制剂。
Objective: To prepare piroxicam nanostructured lipid carrier and investigate its transdermal absorption behavior in vitro. Methods: Piroxicam nanostructured lipid carrier was prepared by a melt-emulsion ultrasonication and low temperature-solidifica- tion method. The physicochemical properties such as appearance, morphology, particle size distribution, PdI and zeta potential of pi- roxicam nanostructured lipid carrier were evaluated. The transdermal absorption in vitro was investigated using Franz diffusion ceils. Results : Piroxicam nanostructured lipid carrier was clear and transparent with small spherical shape as seen under a transmission elec- tron microscope. The particle size distribution, PdI and zeta potential was (106.4 ± 31. 6) nm, (0.217 ± 0.07) and ( -31.6± 2.5 ) mV, respectively. Piroxicam nanostructured lipid carrier had higher cumulative transdermal amount in 12 h than piroxicam solution. Conclusion: The nanostructured lipid carrier can remarkably improve piroxicam permeation into skin, which provides reference for the new dosage form for the topical use of piroxicam.
作者
李旸
陈晨
方志文
Li Yang Chen Chen Fang Zhiwen(Department of Pharmacy, Wuhan Central Hospital of China Construction Third Engineering Bureau, Wuhan 430022, China Department of Pharmacy, Wuhan General Hospital of PLA)
出处
《中国药师》
CAS
2017年第3期416-420,共5页
China Pharmacist
关键词
吡罗昔康
纳米结构脂质载体
体外透皮吸收
热熔乳化超声-低温固化法
Piroxicam
Nanostructured lipid carrier
In vitro transdermal absorption
Melt-emulsion uhrasonication and low tem- perature-solidification method