低血糖生成指数联合低血糖生成负荷饮食对2型糖尿病患者氧化应激及人体测量学指标的影响

Effects of hypoglycemia index and hypoglycemia loaded diet on oxidative stress and anthropometric parameters in patients with type 2 diabetes mellitus

目的 评价低血糖生成指数（GI）联合低血糖生成负荷（GL）饮食干预对2型糖尿病患者血糖、氧化应激水平以及人体测量学指标的影响.方法 将150例2型糖尿病患者按照随机数字表法分为2组,保持2组患者原治疗方案不变.对照组75例,给予传统的食物交换份法进行饮食干预;试验组75例,采用基于低GI联合低GL的食物交换份法进行饮食教育,时间周期为3个月.观察干预前后2组患者空腹血糖、餐后2h血糖、糖化血红蛋白、超氧化物歧化酶、丙二醛、维生素C、维生素E、体质量指数、腰围、上臂肌围、肱三头肌皮褶厚度的变化.结果 干预后对照组空腹血糖、餐后2h血糖、糖化血红蛋白、超氧化物歧化酶、丙二醛、维生素C、维生素E、体质量指数、腰围、上臂肌围、肱三头肌皮褶厚度分别为（10.27±2.67）mmol/L、（11.51±2.54）mmol/L、（8.78±1.95）%、（322.73±51.97）kU/L、（5.80±1.76）μmol/L、（40.78±4.86）μmol/L、（19.33±4.79）μmol/L、（23.94±3.18）kg/m2、（89.57±10.23）cm、（24.10±3.01）cm、（18.38±3.79）mm;试验组分别为（8.76±2.77）mmol/L、（10.63±1.76）mmol/L、（7.96±1.86）%、（357.29±60.04）kU/L、（5.26±1.33）μmol/ml、（44.01±7.06）μmol/L、（21.58±5.25）μmol/L、（22.93±2.75）kg/m2、（86.05±10.79）cm、（22.75±2.86）cm、（16.98±4.48）mm.2组比较差异均有统计学意义（t=2.049~3.769,均P〈0.05）.结论 应用低GI联合低GL饮食干预优于传统的食物交换份干预法,对血糖、氧化应激及人体测量指标均有一定改善,可以提高2型糖尿病患者饮食治疗效果,便于患者居家自我管理.

Objective To evaluate the effects of low blood sugar production index （LGI） combined with low blood sugar production burden （LGL） dietary intervention on blood glucose, oxidative stress and anthropometric indicators in type 2 diabetes mellitus. Methods A total of 150 cases of type 2 diabetes were randomly divided into two groups,maintain the original treatment plan of two groups,75 patients in the control group were given traditional food interchange method for dietary intervention;the experimental group of 75 patients, provide food education based on LGI＋LGI food exchange method , the time period of 3 months. Fasting blood glucose （FPG）、2h postprandial blood glucose （2hPG）, Glycated hemoglobin （HbAlc）, Superoxide dismutase （SOD）, Malondialdehyde （MDA）, Vitamin C, Vitamin E, Body Mass Index （BMI）, Waist circumference （WC） Upper arm muscle circumference （AMC）, Triceps skin fold thickness （TSF） were observed before and after the intervention. Results There were no significant differences in blood glucose, oxidative stress and anthropometry between the two groups （P〉0.05）. After intervention, in the control group： FPG, 2hPG, HbAlc, SOD, MDA, Vitamin C, Vitamin E, BMI, WC, AMC, TSF were （10.27 ± 2.67） mmol/L, （11.51 ± 2.54） mmol/L, （8.78 ± 1.95）%, （322.73 ± 51.97） kU/L, （5.80 ± 1.76）μmol/L, （40.78±4.86）μmol/L, （19.33±4.79）μmol/L, （23.94±3.18） kg/m2, （89.57±10.23） cm, （24.10± 3.01） cm, （18.38 ± 3.79）mm respectively. In the experimental group： they were （8.76 ± 2.77） mmol/L, （10.63 ± 1.76） mmol/L, （7.96 ± 1.86）%, （357.29 ± 60.04） kU/L, （5.26 ± 1.33）μmol/L, （44.01 ± 7.06）μmol/L, （21.58 ± 5.25） μmol/L, （22.93 ± 2.75） kg/m2, （86.05 ± 10.79） cm, （22.75 ± 2.86） cm, （16.98 ± 4.48） mm respectively. There was significant difference between the two groups after intervention （t=2.049-3.769, all P 〈 0.05）. In the experimental group, the improvement of blood sugar, oxidative stress and anthropometry was better than that of the control group （P 〈 0.05）. Conclusions LGI combined with LGL diet intervention is better than the traditional method of food interchange, the blood glucose, oxidative stress and anthropometric indicators have improved, which can improve treatment efficacy in type 2 diabetes and easy for home self-management.