氯吡格雷与阿司匹林治疗脑梗死疗效观察

Observation of curative effect by clopidogrel and aspirin in the treatment of cerebral infarction

目的探讨氯吡格雷和阿司匹林在脑梗死中的防治效果。方法 72例脑梗死患者,随机分为氯吡格雷组和阿司匹林组,各36例。两组均给予相同基础治疗,氯吡格雷组同时给予氯吡格雷,阿司匹林组给予阿司匹林治疗。评定两组患者治疗后不同时间神经功能缺损评分,观察治疗期间不良反应发生情况。结果氯吡格雷组和阿司匹林组治疗24周后神经功能缺损评分量表(NIHSS)评分分别低于本组治疗前与治疗后2、4、12周评分,差异均具有统计学意义(P<0.05)。氯吡格雷组治疗后2、4、12、24周评分和阿司匹林组比较,差异无统计学意义(P>0.05)。氯吡格雷组不良反应发生率为5.6%低于阿司匹林组的25.0%,差异有统计学意义(P<0.05)。结论氯吡格雷和阿司匹林在脑梗死防治中疗效近似,但氯吡格雷不良反应发生率低,值得借鉴。

Objective To investigate preventive and curative effect by clopidogrel and aspirin in the treatment of cerebral infarction. Methods A total of 72 patients with cerebral infarction were randomly divided into clopidogrel group and aspirin group, with 36 cases in each group. Both groups received the same basic therapy, while the clopidogrel group received additional clopidogrel for treatment, and the aspirin group received aspirin instead for treatment. Evaluation was made on national institutes of health stroke scale（NIHSS） scores in different time points after treatment in the two groups. Observation was made on adverse reactions during treatment in both groups. Results Both the clopidogrel group and the aspirin group had lower NIHSS scores after 24 weeks of treatment than those after 2, 4, and 12 weeks of treatment, and their difference had statistical significance（P〈0.05）. There was no statistically significant difference of scores after 2, 4, 12 and 24 weeks of treatment between the clopidogrel group and the aspirin group（P〉0.05）. The clopidogrel group had lower incidence of adverse reactions as 5.6% than 25.0% in the aspirin group, and their difference had statistical significance（P〈0.05）. ConclusionClopidogrel and aspirin provide similar curative effect in treating cerebral infarction, while clopidogrel shows lower incidence of adverse reactions. This method is worth referring.