结肠癌患者中CXCR7及PTEN的表达情况分析

The expression of CXCR7 and PTEN in patients with colon cancer

目的分析结肠癌患者趋化因子受体7(CXCR7)、第10号染色体上磷酸酶和张力蛋白同源缺失的基因(PTEN)在人结肠癌中的表达情况。方法检测本院79例结肠癌患者癌组织CXCR7、PTEN的表达情况,并以癌旁组织为对照,比较患者癌组织与癌旁组织CXCR7、PTEN阳性率。比较癌组织CXCR7、PTEN阳性及其阴性患者的年龄、性别、肿瘤原发部位、肿瘤大小、分化程度、浸润程度、淋巴结转移、TNM分期。结果癌组织中CXCR7阳性表达率为54.43%,高于癌旁组织的12.66%(P<0.05);PTEN阳性表达率为56.96%,低于癌旁组织的92.41%(P<0.05)。癌组织CXCR7阳性患者的淋巴结转移率、(Ⅲ+Ⅳ)患者所占比例高于阴性患者(P<0.05);癌组织PTEN阳性患者中肿瘤>5 cm、高分化、(T3+T4)浸润、淋巴结转移、(Ⅲ+Ⅳ)患者所占比例低于阴性患者(P<0.05)。结论结肠癌患者中淋巴结转移、TNM分期高者多为CXCR7阳性表达,PTEN阳性表达则多出现在TNM分期低、分化程度低、浸润程度低、无淋巴结转移患者中。

Objective To study the expression of chemokine receptor 7（CXCR7）,phosphatase and tensin homolog deleted on chromosome ten（PTEN） and its relationship with pathologic feature in patients with colon cancer.Methods The expression of CXCR7 and PTEN in 79 patients with colon cancer in our hospital were analyzed.The positive rates of CXCR7 and PTEN in cancer tissues and adjacent tissues were compared.Age,sex,primary site of tumor,tumor size,differentiation,invasion,lymph node metastasis,and TNM staging were compared between positive and negative patients.Results The positive expression rate of CXCR7 in cancer tissues was54.43%,which was higher than that in adjacent tissues 12.66%（P〈0.05）.The positive expression rate of PTEN in cancer tissues was56.96%,which was lower than that of in adjacent tissues 92.41%（P〈0.05）.Compared with patients with negative CXCR,the proportion of lymph node metastasis and（III ＋ IV） were significantly higher in patients of positive CXCR7（P〈0.05）.Compared with patients with negative PTEN,the proportion of patients with tumor 5 cm,high differentiation,（T3＋T4） invasion,lymph node metastasis,（III ＋ IV） were significantly lower in patients with positive PTEN（P〈0.05）.Conclusion The lymph node metastasis and advanced TNM staging are related to positive CXCR7,while PTEN positive are found in patients with low TNM stage,low differentiation,low invasion and no lymph node metastasis.