摘要
目的:探讨新生儿中枢神经系统感染确诊中肿瘤坏死因子检测价值。方法:选取中枢神经系统感染新生儿80例,其中病毒性脑炎40例(病脑组),细菌性脑膜炎40例(化脑组),同时取40例无中枢神经系统感染的癫痫和手足抽搐症患儿作对照组,分析检测脑脊液和血清中的TNF含量,并进行对比。结果:化脑组选取的新生儿脑脊液、血清TNF水平明显高于病脑组和对照组,具统计学差异(P<0.05)。病脑组TNF水平也显著高于对照组,具统计学差异(P<0.05),且在化脑组,脑脊液与血清TNF水平呈正相关(P<0.05)。结论:脑脊液中所含的TNF水平可作为临床诊断细菌性脑膜炎的一项较为重要的指标,脑脊液TNF变化可通过血液中TNF水平反映,并为日后采用抗TNF抗体对感染性疾病治疗提供了有力参考依据。
Objective： Objective To investigate the value of tumor necrosis factor （TNF） in the diagnosis of central nervous system infection in neonates. Methods： 40 cases of viral encephalitis, 40 cases of bacterial meningitis and 40 cases of epilepsy and hand-foot -twitch without central nervous system infection were selected. Children as the control group, analysis of cerebrospinal fluid and serum levels of TNF, and for comparison. Results： The cerebrospinal fluid （CSF） and serum TNF levels in the neonatal group were sig- nificantly higher than those in the brain and control groups （P -0.05）. （P -0.05）. The level of TNF in the brain and cerebrospinal fluid was also significantly higher than that in the control group （P -0.05）. Conclusion： TNF levels in cerebrospinal fluid can be used as a clinical diagnosis of bacterial meningitis is a more important indicator of cerebrospinal fluid TNF changes can be reflected by the level of TNF in the blood, and for the future use of anti-TNF antibody treatment of infectious diseases provides a strong reference in accordance with.
