慢性心衰患者C-反应蛋白、心肌肌钙蛋白I及糖类抗原CA125的检测结果

Value of combined detection of C-reactive protein,cardiac troponin I and carbohydrate antigen CA125 in patients with chronic heart failure

目的探讨C-反应蛋白（CRP）、糖类抗原125（CA125）、心肌肌钙蛋白Ⅰ（cTnI）3项指标联合检测在慢性心力衰竭（CHF）诊断中的应用价值。方法择取2014年5月到2016年5月山东德州市中医院治疗的60例CHF患者（CHF患者组），选择同期在本院进行体检的健康受检者60例（健康对照组）。取受试者禁食后第2日清晨空腹静脉血，检测两组CRP、CAl25、cTnI的结果，并比较CHF不同心功能患者3项指标的差异。结果CHF患者组CRP、CA125、cTnI3项指标测定值均明显高于健康对照组[CRP（mg／L）：9．02±4．06比2．20±1．19，CA125（U／L）：47．95±6．03比6．51±0．47，cTnI（LLg／L）：0．49±0．04比0．02±0．01，P均〈0．05]，并且心功能Ⅲ～Ⅳ级CHF患者上述3项指标测定结果也明显高于心功能Ⅰ，Ⅱ级患者[CRP（mg／L）：13．75±3．61比3．88±1．72，CA125（U／L）：65．74±7．12比14．18±2．56，cTnI（μg/L）：0．49±0．04比0．11±0．02，P均〈0．05]。结论CRP、CA125、cTnI 3项指标检测可以应用于CHF的临床诊断，其测定结果高低直接与患者心功能等级相关。

Objective To investigate application value of C-reactive protein （CRP） , carbohydrate antigen 125 （CA125）, cardiac troponin I （cTnI） 3 indicators Joint detection in the diagnosis of chronic heart failure （CHF） . Methods 60 cases of CHF were selected from May 2014 to May 2016 in Dezhou Hospital of Traditional Chinese Medicine （CHF group） , 60 healthy subjects were selected as a healthy control group at the same period in our hospital. Fasting venous blood samples were collected at The second day morning after fasting, and CRP, CA125 and cTnI were detected in the two groups , and the difference of 3 indicators in CHF patients with different cardiac function were compared. Results Measurements of CRP, CA125, cTnI in CHF group were significantly higher than healthy controls [ CRP （mg/L） ： 9.02 ± 4.06 vs. 2.20 ± 1.19, CA 125 （U/L） ： 47.95 ± 6.03 vs. 6.51 ± 0.47, cTnI （g/L） ： 0.49 ± 0.04 vs. 0.02 ± 0.01, P all 〈 0.05 ], the above three indicators measuring results of CHF patients with Cardiac function grade Ⅲ - Ⅳ were higher than that of CHF patients with class Ⅰ - Ⅲ CRP （mg/L） ： 13.75±3.61 vs. 3.38± 1.72, CA125 （U/L） ： 65.74±7.12 vs. 14.18±2.56, cTnI （g/L） ： 0.49±0.11 vs. 0.04±0.02, P all 〈 0.05 ]. Conclusion CRP, CA125, cTnl can be applied to clinical diagnosis, its determination result directly related to the cardiac function grade of CHF patients.