临汾地区丙型肝炎病毒感染检测结果分析

Analysis of the laboratory test results about Hepatitis C virus(HCV) in Linfen region

目的了解本地区普通人群中丙型肝炎病毒（HCV）感染实验室检测情况。方法收集2015年1月1日至12月31日来山西省临汾市人民医院就诊的申请检测丙型肝炎病毒抗体（抗-HCV）的门诊及住院患者标本共21120例，采用酶联免疫吸附试验（ELISA）进行抗-HCV的筛查，对ELISA筛查阳性的标本采用实时荧光定量聚合酶链式反应（PCR）法进行丙型肝炎病毒核酸（HCVRNA）检测。结果21120例标本中抗-HCV筛查阳性率为0．69％（146／21120）；在146例抗-HCV标本中其中47例检测出HCVRNA，检出率为32．2％（47／146）；检测出HCVRNA标本的抗-HCV的浓度试剂测量值，阳性判定值之比值（S／CO值）介于8．32～25．80（〉8．0）。结论在山西临汾地区就诊的普通人群中抗-HCV阳性分布比例以及HCVRNA检出率均较低，可检出HCVRNA的患者抗-HCV浓度相对较高。

Objective To know the condition of HCV test results among the general population in Linfen region. Methods 21 120 cases were collected that outpatient and inpatient need to test the hepatitis c virus antibody （anti-HCV） from January 1 to December 31, 2015 in Linfen people＇s hospital, Shanxi Province, with screening the anti-HCV by enzyme-linked immunosorbent assay （ELISA） , and the hepatitis C virus nucleic acid （HCV RNA） was detected by real-time fluorescence quantitative polymerase chain reaction （PCR） for anti-HCV positive specimens. Results There were 146 （0.69%） anti-HCV positive among 21 120 cases, there were 47 cases that HCV RNA could be detected among the 146, detection rate was 32.2%. The concentration of the anti-HCV （S/CO value） was between 8.32 - 25.80 （〉 8.0） among HCV RNA positive specimens. Conclusion Anti-HCV positive distribution proportion in the general population and HCV RNA detection rate were low in Linfen region, the concentration of the anti-HCV （S/CO value） was relatively higher in the patients with HCV RNA positive.