精神分裂症住院患者吸烟与认知功能相关性研究

A related study of smoking and cognitive functions in inpatients with schizophrenia

目的探讨精神分裂症住院患者吸烟与认知功能的相关性。方法将83例精神分裂症住院患者根据吸烟情况分为吸烟组和不吸烟组,采用一般情况调查表、自编吸烟情况调查表、尼古丁依赖检测量表(FTND)、一氧化碳监测仪(pi CO+Smokerlyzer)、重复性成套神经心理状态测验(RBANS)和阳性和阴性综合征量表(PANSS)进行测试。结果吸烟组患者年龄较大、发病年龄较晚(P<0.05)。FTND的总分结果显示,吸烟组患者大多数为轻中度尼古丁依赖患者。患者吸烟的原因主要是习惯(46.7%)和缓解压力(26.7%),60%的患者曾经尝试戒烟。吸烟组RBANS的延迟记忆因子分低于不吸烟组(P<0.05)。结论有吸烟习惯的精神分裂症住院患者存在一定的认知功能损害。

Objective To explore the relationship between smoking and cognitive functions in inpatients with schizophrenia. Methods A total of 83 inpatients were divided into smoking group and non-smoking group according to whether they are smokers. They were assessed with general information questionnaire, self-designed smoking condition questionnaire, Fagerstrom Test of Nicotine Dependence（FFND） , piCO ＋ Smokerlyzer, Repeatable Battery for the Assessment of Neuropsychologieal Status （RBANS） and Positive and Negative Symptom Scale（PANSS）. Results Patiens in smoking group were significantly older than those in non-smoking group（P 〈0.05 ） and the morbidity age in smoking group was significantly later than that in non-smoking group（ P 〈 0.05 ）. The total score of FTND showed that most patients in smoking group belonged to mild and moderate nicotine dependence. The reasons of smoking in the patients included habit （46.7%） , remission （26.7%） and 60% of the patients had tried to quit smoking. The delayed memory index score of RBANS in smoking group was significantly lower than that in non- smoking group （ P 〈 0.05 ）. Conclusion There is impairment of cognitive function in the schizophrenic inpatients with smoking.