等渗和低渗造影剂在冠状动脉介入诊疗中对肾功能的影响分析

Analysis of the Effects of Isotonic Contrast Agent and Hypotonic Contrast Agents on Renal Function in Percutaneous Coronary Intervention

目的探究冠状动脉介入诊疗中采用等渗和低渗造影剂对患者肾功能的影响。方法选取冠状动脉介入诊疗患者120例,时间为2015年1月-2016年5月,随机分为两组,分别给予等渗以及低渗造影剂,对比两组术后血清肌酐水平以及造影剂肾病的发生率。结果两组冠状动脉介入诊疗患者的血清肌酐水平在术后1天以及术后14天相比,差异无统计学意义（P〉0.05）。实验组冠状动脉介入诊疗患者造影剂肾病的发生率（8.33%）与对照组造影剂肾病的发生率（6.67%）相比,差异无统计学意义（P〉0.05）。结论冠状动脉介入诊疗患者接受等渗以及低渗造影剂,并不会对血清肌酐水平造成明显的影响,2种造影剂在患者出现造影剂肾病方面相比,并不存在明显的区别。

Objective To explore the effect of isotonic and hypotonic contrast agents on renal function in patients undergoing coronary intervention. Methods From January 2015 to May 2016,120 patients with coronary artery intervention were selected and randomly divided into two groups,whom were given isotonic and hypotonic contrast agents respectively. The serum creatinine levels and the incidence of radiographic contrast nephropathy were compared between the two groups. Results There was no significant difference in serum creatinine level between the two groups at 1 th day and 14 th day after the surgery（P〈0.05）. There was no significant difference in the incidence of radiographic contrast nephropathy between the experimental group（8.33%） and the control group（6.67%）,and the difference was not statistically significant（P〉0.05）. Conclusion Isotonic and hypotonic contrast agents do not have a significant effect on serum creatinine levels of patients with coronary intervention. There is no significant difference between the two contrast agents in terms of radiographic contrast nephropathy.