吗丁啉联合达吉对老年功能性消化不良患者胃动力及血清PG、G-17水平的影响

Effect of motilium combined with dages on gastric dynamics,pepsinogen and gastrin-17 of senile functional dyspepsia patients

目的探讨吗丁啉(多潘立酮)联合达吉(复方消化酶)对老年功能性消化不良(FD)患者的胃动力以及血清胃蛋白酶原(PG)、胃泌素-17(G-17)水平的影响。方法选取2014年3月至2016年3月接受治疗的84例老年FD患者,随机分为对照组和试验组,每组各42例,对照组患者仅给予口服吗丁啉治疗,试验组在对照组治疗基础上联合达吉治疗,对比分析两组的临床疗效和临床症状改善情况,比较两组治疗前后血浆瘦素(LEP)、胃动素(MTL)、促肾上腺皮质激素释放激素(CRH)、PGⅠ、PGⅡ及G-17水平。结果对照组的临床治疗总有效率为66.67%,试验组为90.48%(P<0.05);治疗后对照组各临床症状改善率显著低于试验组(P<0.05);治疗后两组的餐前LEP、餐后LEP和MTL水平较治疗前均显著升高,CRH水平则明显降低(P<0.05),试验组治疗后餐前LEP、餐后LEP和MTL含量均显著高于对照组,CRH水平显著低于对照组(P<0.05);治疗后两组的血清PGⅠ、PGⅡ和G-17水平较治疗前均明显升高,胃蛋白酶原比值(PGR)则明显降低(P<0.05),试验组治疗后血清PGⅠ、PGⅡ和G-17水平均显著高于对照组,PGR显著低于对照组(P<0.05)。结论吗丁啉联合达吉治疗老年FD患者的临床效果显著,对胃动力的恢复有显著促进作用,还可显著提升患者血清PG和G-17的水平。

Objective This paper explores the effect of motilium（domperidone）combined with dages（compound digestive enzymes）on senile functional dyspepsia patients and on gastric dynamics,pepsinogen（PG）and gastrin-17（G-17）. Methods Eighty-four elderly patients with functional dyspepsia treated from March 2014 to March 2016 were randomly assigned to the control group and the experimental group（42 cases in each group）.The control group was given motilium treatment and the experimental group was treated with motilium combined with dages.The clinical treatment effect and clinical symptom improvement rate of the two groups were compared.The levels of leptin（LEP）,motilin（MTL）,corticotropin releasing hormone（CRH）,PGⅠ,PGⅡ and G-17 were compared before and after treatment.Results It was found that the total effective rate of the control group was 66.67%,and that of the experimental group was 90.48%（P〈0.05）.After treatment,the clinical symptom improvement rate of the control group was found to be significantly lower than that of the experimental group（P〈0.05）;the LEP level before meals,the LEP level after meals and MTL in the two groups were significantly higher;the CRH level was significantly lower（P〈0.05）;the LEP level before meals,LEP level after meals and MTL in the experimental group were significantly higher than those in the control group but the CRH level was significantly lower than that in the control group（P〈0.05）;the PGⅠ,PGⅡ and G-17 levels in the two groups were significantly higher but the PGR was significantly lower（P 0.05）;the PGⅠ,PGⅡ and G-17 levels in the experimental group were significantly higher than those in the control group but the PGR was significantly lower than the control group（P〈0.05）.Conclusion Motilium combined with dages has more significant clinical effect on senile functional dyspepsia patients,and can promote the recovery of gastric motility.It also has obvious advantages in improving the levels of PG and G-17.