沙格列汀联合胰岛素治疗2型糖尿病的疗效及安全性观察

Observation of the efficacy and safety of Saxagliptin combined with insulin treating type 2 diabetes

目的:探讨沙格列汀联合胰岛素治疗2型糖尿病的疗效及安全性。方法:80例2型糖尿病患者随机分为观察组和对照组,各40例,均皮下注射胰岛素,观察组联合沙格列汀,比较两组患者治疗前后的空腹血糖(FBG)、餐后2h血糖(2h PG)、糖化血红蛋白(HbA1c)、空腹血清C肽、餐后2h血清C肽值、胰岛素用量及低血糖发生率。结果:治疗后,两组FBG、2h PG、HbA1c水平、胰岛素用量均降低,且观察组各指标比对照组下降更明显(P<0.05),且观察组空腹血清C肽、餐后2h血清C肽水平均显著高于对照组(P<0.05),低血糖发生率明显低于对照组(P<0.05)。结论:沙格列汀联合胰岛素治疗2型糖尿病可有效控制血糖、减轻胰岛素抵抗、降低低血糖发生率。

Objective：To discuss the efficacy and safety of Saxagliptin combined with insulin treating type 2 diabetes.Methods：80patients with type 2 diabetes were randomly divided into observation group and control group,40 cases in each group,all patients were given subcutaneous insulin,observation group added saxagliptin.Fasting blood glucose（FBG）,2h postprandial blood glucose（2h PG）,HbAlc,fasting serum C-peptide,2h postprandial serum C-peptide,insulin dosage and the incidence of hypoglycemia before and after treatment were compared.Results：After treatment,FBG,2h PG,HbAlc level,and insulin dosage all decreased,observation group decreased more than control（P〈0.05）;fasting serum C-peptide and 2h postprandial serum C-peptide level of observation group were significantly higher than control（P〈0.05）,the incidence of hypoglycemia was significantly lower than control（P〈0.05）.Conclusion：Saxagliptin combined with insulin can effectively control blood glucose,reduce insulin resistance,and reduce the incidence of hypoglycemia.