期刊文献+

评价不同治疗方案对多发性硬化的疗效及不良反应

下载PDF
导出
摘要 目的:评价不同治疗方案对多发性硬化的疗效及不良反应;方法:通过随机方式将80例多发性硬化患者分成对照组和实验组,每组各40例,对照组患者采用常规方式进行治疗,实验组患者则在常规治疗的同时,给予β干扰素治疗;结果:实验组患者的临床治疗总有效率显著高于对照组患者(P<0.05);在不良反应发生率方面两组患者比较差异无统计学意义(P>0.05)。结论:在对多发性硬化进行治疗时,在常规治疗的基础上,给予β干扰素辅助治疗,能让临床治疗效果显著提高,安全可靠,具有临床推广价值。 Objective: evaluation of different treatment of multiple sclerosis of the efficacy and adverse reaction; Methods: through the random way the 80 cases of patients with multiple sclerosis is divided into control group and experimental group, each with 40 cases in each, control group were treated with routine treatment, patients in the experimental group is in the conventional treatment at the same time, giving interferon beta therapy. Results: the total efficiency of the clinical treatment of patients in the experimental group was significantly higher than that of the control group (P 〈 0.05) ; in adverse reactions occurred difference in rate of the patients of the two groups had no statistical significance (P〉 0.05). Conclusion: in the treatment of multiple sclerosis, on the basis of conventional treatment, the treatment of interferon beta interferon can significantly improve the clinical treatment effect, safe and reliable, with clinical value.
作者 李馨 李天明
出处 《中国农村卫生》 2016年第09X期10-11,共2页
关键词 多发性硬化 Β干扰素 疗效 不良反应 Multiple sclerosis Interferon beta curative effect Adverse reaction
  • 相关文献

参考文献3

二级参考文献21

  • 1Frederik Barkhof, Mara Rocca, Gordon Francis, et al.Validation of Diagnostic Magnetic Resonance ImagingCriteria for Multiple Sclerosis and Response to Inteiferon.
  • 2Pakdaman H,Sahraian MA, Fallah A, et al.Effect ofearly interferon beta-la therapy on conversion to multiplesclerosis in Iranian patients with a first demyelinatingevenifj].Acta Neurol Scand, 2007,115: 429-431.
  • 3O Andersen, I Elovaara, M Fa, et al. Multicentre,randomised, double blind, placebo controlled, phase IIIstudy of weekly, low dose,subcutaneous interferon beta-la in secondary progressive multiple sclerosis[J].NeurolNeurosurgPsychiatry,2004, 75: 706-710.
  • 4Yann Mikaeloff, Guillaume Caridade, Marc Tardieu,et al.Effectiveness of early beta interferon on the firstattack after confirmed multiple sclerosis : A comparativecohort study[J].Official Journal of the European PaediatricNeurology Society,2008,12: 205-209.
  • 5Chris H, Polman,Ludwig Kappos,et al.Risk of developingMS and treatment effect of interferon beta-1 b[J].FreedmanNeurol,2008,255: 480-487.
  • 6X Montalban, J Sastre-Gaxriga, M Tintore, et al.A single一center, randomized, doubleblind, placebo-controlledstudy of interferon beta-lb on primary progressive andtransitional multiple sclerosis[J].Multiple Sclerosis, 2009,15 ( 10): 1195-1205.
  • 7Giancarlo Comi, Massimo Filippi,Frederik Barkhof,et al.Effect of early interferon treatment on conversion todefinite multiple sclerosis:a randomised study[J].Lancet,2001,357: 1576-1582.
  • 8L.Kappos, A.Traboulsee, C.Constantinescu,et al.Long-term subcutaneous interferon beta-la therapy in patients withrelapsing-remitting MS[J].Neurology, 2006,67 : 944-953.
  • 9Ludwig Kappos, Mark S Freedman, Chris H Polman,et al.Long-term effect of early treatment with interferonbeta-lb after a first clinical event suggestive of multiplesclerosis:5-year active treatment extension of the phase 3BENEFIT trial[J].Lancet Neurol,2009,8 : 987-997.
  • 10张国勇,蒋宁,翁益云,张旭.β-干扰素治疗继发进展型多发性硬化临床疗效的荟萃分析[J].中国神经免疫学和神经病学杂志,2008,15(2):88-91. 被引量:3

共引文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部