变应性鼻炎鼻激发后鼻腔分泌物嗜酸性粒细胞增加与血清特异性IgE水平正相关

Increased eosinophils in nasal exudation after allergic rhinitis nasal provocation are positively correlated with serum level of specific IgE

目的探讨变应性鼻炎特异性鼻黏膜激发试验(SNPT)与血清特异性IgE(sIgE)在变应性鼻炎患者检测中的一致性,并对激发前后嗜酸性粒细胞(EOS)百分比和血清sIgE相关性进行分析。方法对80例常年性尘螨变应性鼻炎患者进行SNPT,Unicap检测血清sIgE的等级,采用Kendall’s tau_b检验对激发前后鼻腔分泌物中EOS百分比进行相关性分析。结果患者鼻黏膜激发试验阳性与血清sIgE阳性有一定相关性,且SNPT后鼻分泌物中EOS百分比的增加与sIgE等级呈正相关。结论鼻黏膜激发试验阳性可以作为过敏性鼻炎的一个诊断指标,激发前后鼻腔分泌物中EOS的百分比变化也可以用于评价过敏性鼻炎的严重程度。

Objective To study the relationship between specific nasal provocation test（ SNPT） and serum specific IgE level in the patients with allergic rhinitis,and analyze the correlation between the eosinophil（ EOS） percentage in nasal secretion and serum specific IgE level. Methods SNPT was performed in 80 cases of perennial allergic rhinitis due to dust mites. Specific IgE in the serum of those patients was detected by Unicap. EOS percentage in nasal secretions was recorded before and after SNPT. The correlation of EOS percentage and serum level of specific IgE was analyzed by Kendall＇s tau_b test. Results The positive result of SNPT had a concordance with serum specific IgE in recruited patients. And the increased EOS percentage in nasal secretions after SNPT had a positive correlation with the level of serum specific IgE. Conclusion Positive SNPT can be used as a diagnostic index of allergic rhinitis. And the increased percentage of EOS in nasal secretions after SNPT can also help evaluate the severity of allergic rhinitis.