摘要
A stable and commercially available reagent mixture,composed of tetrabutylammonium bifluoride/potassium bifluoride（TBAF/KHF_2）,was found to be effective for the nucleophilic ring opening reactions of sugar-derived epoxides with fluoride.Different sugar-derived epoxide precursors,including 1-thioglycosides can be ring-opened to afford fluorinated carbohydrate products in high yields and in short reaction times.
A stable and commercially available reagent mixture,composed of tetrabutylammonium bifluoride/potassium bifluoride（TBAF/KHF_2）,was found to be effective for the nucleophilic ring opening reactions of sugar-derived epoxides with fluoride.Different sugar-derived epoxide precursors,including 1-thioglycosides can be ring-opened to afford fluorinated carbohydrate products in high yields and in short reaction times.
基金
the National Natural Science Foundation of China (No. 21502076) for the financial support
